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Búsqueda de socios en el sector de biotecnología industrial que trabajen con microbios para formar un consorcio y presentar una propuesta a la convocatoria de proyectos en el marco ERA-Net CoBioTech


Búsqueda de socios
Una red británica de biotecnología está formando un consorcio y preparando una propuesta para la convocatoria de proyectos en el marco ERA-Net CoBioTech. El consorcio busca socios industriales especializados en trabajar con microbios (preferiblemente corynebacterium o levadura) en el sector de biotecnología industrial. El proyecto tiene como objetivo estudiar el comportamiento de membranas con vistas a adaptarlas y mitigar el efecto de las toxinas durante procesos de biotecnología industrial, aumentando así la productividad. La fecha límite de la convocatoria es el 2 de marzo de 2017 y el plazo para presentar expresiones de interés finaliza el 30 de enero.


Industrial biotechnology partners working with microbes sought for a consortium applying for ERA-Net CoBioTech
A UK industrial biotechnology network is preparing a consortium and proposal to address the ERA-Net CoBioTech call. The consortia is seeking industrial partners of any size working with microbes (preferably corynebacterium or yeast) in the industrial biotechnology sector. The project will study the behavior of membranes with a view to tuning them and subsequently mitigating the effect that toxins have during industrial biotechnology processes and so increasing yields.
Many industrial biotechnology (IB) processes aspire to generate (bio-based) molecules which are ultimately toxic to the producing cell factory. In addition to toxicity towards intracellular components, the lipid membrane and associated proteins are vulnerable to damage by these compounds and physical stresses such as pH and temperature. Indeed, it is well-established that the membrane composition is altered in bacteria in response to stresses such as temperature and solvent production. It is also well-established that substrate toxicity can be detrimental to a range of IB processes and much of this will involve toxicity towards cell membrane components. As such an approach whereby membranes can be "tuned", both in terms of their lipid and protein content is desirable to mitigate these toxic effects. Production of higher concentrations of the desired molecules makes such bioprocesses more efficient, increasing product yield, reducing cost, and helps drive the move away from fossil-based raw materials.

This project directly addresses two of the CoBioTech topics. "Sustainable production and conversion of different types of feedstocks and bioresources into value-added products" and "Sustainable industrial processes". Production of value-added products often utilises microbial technologies and these can be made more sustainable by optimisation of the process. We envisage that the approach and tools developed within this project will be widely applicable across the sector - it is not limited to particular microbes or products and has scope to be expanded to address challenges of other production conditions which conflict with microbial growth e.g. pH and temperature.

This project includes participants with multidisciplinary scientific backgrounds and will combine biotechnologically based industries and research institutions across the countries eligible for this funding call.

This project will take an iterative approach which combines state-of-the-art -omics techniques, lipid membrane biochemistry and modelling, molecular dynamics simulations and bacterial genetics to generate strains which are more resistant to the desired molecules. Strains chosen will be those of industrial relevance e.g. Corynebacterium or yeast. There will be a focus on production of natural products which are highly desirable. This approach allows improvement of microbial strains guided by underlying physiological responses; this approach is therefore transferrable to any microbial strain. Our project is intersectorial, cross-disciplinary and links transnational expert partners.

Industrial partners of any size are sought from the biotechnology sector. The partner(s) should be experienced working with microbes (eg. Corynebacterium or yeast) and wish to participate in the engineering of microorganisms for the production of biotechnologically interesting small metabolites such as plant polyphenols, amino acids and alcohols.

Call title: "Biotechnology for a sustainable bioeconomy" ERA-Net Cofund Action under Horizon 2020
Budget: -Y-euro;36m
EOI deadline: January 30th 2017
Call deadline: 2nd March 2017 (pre-proposals)

Partner sought

Partner Sought:
Type of partner - SME or larger Specific area of activity - industrial biotechnology Field of expertise - processes using microbes Task to be performed - industrial partner
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R-Y-D Institution
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Evaluation Scheme:
Two stage
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Coordinator Required:
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