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Eurostars 2: Herramienta analítica personalizada para la monitorización inmune en pacientes con trasplante de hígado

Resumen

Tipo:
Búsqueda de socios
Referencia:
RDES20160805001
Publicado:
12/08/2016
Caducidad:
12/08/2017
Resumen:
Una pyme española busca un socio europeo para desarrollar un sistema de análisis clínicos que permita la monitorización inmune periódica en recipientes de trasplante de hígado mediante un simple análisis de sangre. Los socios buscados se encargarán de diseñar, fabricar y validar el sistema microfluídico, así como de la validación de los resultados experimentales. La empresa también busca socios del sector sanitario (médicos) con acceso a biopsias de trasplante de hígado. La fecha límite de la convocatoria es el 15 de septiembre de 2016 y el plazo para presentar expresiones de interés finaliza el 31 de agosto. El proyecto tendrá una duración de un año.

Details

Tittle:
Eurostars 2: Personalized analytical tool for immune monitoring in liver transplant patients.
Summary:
Spanish SME looks for a partner in Europe for the development of a clinical analytic system, which enables periodic immune monitoring in liver transplant recipients through a simple blood test. The role of the partners sought is related to microfluidic system design, manufacturing and validation, as well as experimental results validation. They are also seeking partners in the health sector (clinicians) with access to liver transplant biopsies.
Description:
This biotechnology company is focused on the development of biotechnological tools for the identification of new biomarkers and therapeutic targets as well as for the discovery of new drugs. The core technology is based on cell membrane microarrays. These microarrays consist of multiple microdots of membranes isolated from different organs and tissues. This single miniaturized assay allows characterizing the action of drugs in several organs simultaneously, with consequent savings in time, reagents, experimental animals and pollutants.

The host immune system monitoring after a transplant is crucial to ensure the survival not only of the graft but also of the transplant patient, owing to the fact that the chronic immunosuppression is linked to a higher risk for having a wide swath of health problems including neoplasia "de novo", which are present in the 25% of the patient treated for 5 years. However, currently available "in vitro" assays exhibit limited predictive and diagnostic capacities, mainly due to the inherent constraints of the analyzed biomarkers and to the availability of donor´s samples. As an alternative to these techniques, our company proposes the development of a clinical analytic system, which enables periodic immune monitoring in liver transplant recipients through a simple blood test.
This diagnostic tool will be comprised of an analytical fungible cartridge and a reading device. The cartridge will be a customized microfluidic chip in which cell membranes isolated from the blood and the organs of both, the donor and the recipient will be immobilized. As the disposable chip developed will be customized with the cell membranes isolated from the donor and the recipient, all the characteristic antigens of both will be present, including those exposed by the HLA (Human Leukocyte Antigen) complexes. To do that, the microfluidic technology will be combined, on one hand, with microarrays methodology, which allows the production of a large number of chips with the reduced amount of sample obtained at time of surgery, and on the other hand, with our company´s technology that enables the immobilization of cell membranes over supports preserving the structure and function of their proteins. Each chip could be subsequently incubated with the blood of the transplant recipient using the reading device which automatically performed the evaluation of the humoral immune response, increasing, in this way, the frequency of the recipient´s immune function monitoring.
Therefore, the proposed system will allow both, early detection of rejection episodes and fine adjustment of immunosuppressant doses, contributing to minimize drug toxicity and treatment-related pathologies such as neoplasia. In conclusion, the diagnosis provided with this tool will increase the cost-effective ratios of transplant surgery as well as the patients´ expectancy and quality of life.

The company is looking for EU SME´s or research organisations with expertise in microfluidics and lab-on-a-chip techniques, as well as clinicians in the health sector with access to liver transplant biopsies.

Deadline for call: 15/09/2016
EOIs deadline: 31/08/2016
Project duration: 1 year
Advantages and Innovations:
Easier and more simple immune monitoring in patients through a blood test.
Early detection of rejection episodes.
Adjustment of medical doses leading to less toxicity and derived pathologies such as neoplasia.
Higher cost-effective ratios of transplant surgery as well as patients´ expectancy and quality of life.
Stage of Development:
Concept stage
Technical Specification or Expertise Sought:
The partners sought should have experience in microfluidics and lab-on-a-chip techniques, as well as partners in health sector (clinicians) with access to liver transplant biopsies to carry out the following tasks:
a) microfluidic chip design, development and validation.
b) sample acquisition and processing, immune monitoring results validation.
IPR Status:
Secret Know-how,Patents granted
Comments Regarding IPR Status:
Patents licenced and secret know-how.
The technology is protected by two patents that have been licensed by the Basque Country University to the company and whose authors are the promoters of the company. This implies that previous and in depth "state-of the art" and patentability searches have been conducted, being this a first step to enable freedom to operate.

Partner sought

Partner Sought:
A company is sought, with expertise in microfluidics and lab-on-a-chip techniques with experience in the development and manufacturing of microfluidic devices (chips) in different plastic materials. Is desirable that this biochips are compatible with colorimetric/fluorometric readers in the market, and/or the capability to develop and manufacture a tailored colorimetric/fluorometric reader for this biochip. The tasks assigned in the project will be related to microfluidic chip design, development and validation. Clinicians are sought with expertise in liver transplantation and related immune monitoring, in a company, university or hospital with access and authorization to manipulate (for research activities) human liver transplant biopsies. Experience in immune monitoring of patients is highly desired, as the tasks assigned in the project will range from sample/biopsies acquisition and proccessing, to validation of immune monitoring results obtained in the project vs conventional/existing techniques.
Type of Partnership Considered:
RDR

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Spanish

Dissemination

Programme-call

Anticipated Project Budget:
to be discussed with partners
Coordinator Required:
No
Deadline for Call:
15/09/2016
Funding Scheme:
Collaborative projects
Project Duration:
144
Weblink to the Call:
Project title and Acronym:
to be defined