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H2020-FET-OPEN: Descubrimiento de nuevos compuestos para mantener una microbiota intestinal saludable mediante modelado molecular métrico

Resumen

Tipo:
Búsqueda de socios
Referencia:
RDBG20150626001
Publicado:
06/07/2015
Resumen:
Una universidad y una empresa búlgaras están interesadas en presentar una propuesta a la convocatoria H2020-FETOPEN-2014-2015-RIA con el objetivo de identificar y validar compuestos naturales y sintéticos de consumo masivo para mantener una microbiota intestinal saludable. En el proyecto se utilizará una plataforma única de modelado molecular cuántico que permita caracterizar nuevos promotores de microbios saludables e inhibidores de microbios asociados a enfermedad. Se busca un coordinador en los campos de química orgánica, microbiología y modelos animales translacionales. La fecha límite de la convocatoria es el 19 de septiembre de 2015 y el plazo para presentar expresiones de interés finaliza el 1 de septiembre.

Details

Tittle:
H2020-FET-OPEN: Discovery of novel compounds promoting health beneficial microbiota through metric molecular modelling-looking for partners and coordinator
Summary:
Bulgarian University and a R&D company propose for H2020-FETOPEN-2014-2015-RIA to identify and validate novel safe and suitable for mass consumption natural and synthetic compounds for enhancing healthy gut microbiota. Unique platform for quantum molecular modeling will be used to characterize new promoters of healthy microbes and inhibitors of disease-associated microbes. Partners and coordinator are sought in the field of organic chemistry, microbiology and translational animal models.
Description:
The definitive health outcomes of so-called pre- and probiotics and their mechanisms of effect are gradually uncovered and there is currently much interest in increasing numbers and activities of health beneficial bacteria in the large gut, preferably by supressing the harmful species.

As diet is the main factor controlling the intestinal microflora, it is possible to modulate the composition of the microflora through foods and/or natural products. The project looks for identification and characterization of prebiotic substrates that are selectively utilized by bifidobacteria and lactobacilli of the indigenous gut flora as well as novel compounds and natural products that actively inhibit potential pathogens such as toxin-promoting clostridia, proteolytic bacteroides and toxigenic Esherichia coli.

In this manner, a 'healthier' microflora composition is obtained whereby the bifidobacteria and/or lactobacilli become predominant in the intestine and brings possible health-promoting effects. The substrates, natural products and compounds promoting a healthy microbiome will be discovered using an original quantum similarity approach and other methods developed by the Bulgarian R&D company in the project, while their testing and characterization will be performed in the collaborators' laboratories. The R&D company's molecular discovery approach is based on iterative, multi-step quantum-similarity procedure for compound identification. The methodology enables discovery of novel active compounds with quantum components representing multiple desired pharmacological properties. Since it uses quantum rather than chemical similarity, it is capable of discovering active compounds outside of known structural classes - molecules, which appear chemically dissimilar may be similar on a quantum level, and vice versa.

Partners and coordinator are sought in the field of organic chemistry, microbiology and translational animal models to contribute to the research and validation activities in the project.

The project will be submitted for the H2020-FETOPEN-2014-2015-RIA call as Research and Innovation Action.

The call supports a large set of early stage, high risk visionary science and technology collaborative research projects is necessary for the successful exploration of new foundations for radically new future technologies.

Deadline of the call: 29 September 2015.
Deadline for EoI:1 September 2015.

More information about the call: http://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/11052-fetopen-ria-2014-2015.html#tab1
Advantages and Innovations:
Disruptions to the normal microbial balance in the gut have been associated with obesity, malnutrition, inflammatory bowel disease, neurological disorders and cancer. Current studies have suggested that gut bacteria influence mood-related symptoms and even behaviour in humans. The project aims to employ an innovative and original therapeutic strategy that includes (1) a biological strategy that targets entire complex ecological communities and metabolic pathways, and (2) an original platform based on quantum representation of chemical structures and machine-learning fuzzy-decision algorithms.

The R&D company in the project has developed a theoretical framework for systematic small molecule discovery based on well-defined, easily computable, localized molecular attributes (quantum components), and introduces a proper metric (quantum similarity) in the chemical modeling space. As a result, the computational platform has unique capabilities for identification of novel active compounds.

The methodology has been successfully applied and experimentally validated against a variety of targets, discovering structurally novel compounds against blood- and liver stage-malaria; novel, non-toxic, bioavailable modulators of Nrf2 that penetrate the blood-brain-barrier, and others.
Stage of Development:
Proposal under development

Partner sought

Partner Sought:
Partners and coordinator are sought in the field of: - organic chemistry, microbiology and translational animal models to complement the research and validation activities of the discovered healthy compounds as collaborative laboratories. Partners may be: - R&D centres - Higher Education Institutes/Universities - Companies - Public or Private.
Type of Partnership Considered:
RDR

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English

Dissemination

Programme-call

Coordinator Required:
Si
Deadline for Call:
29/09/2015
Project Duration:
0