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H2020 FTI Pilot 2015-1: Producción continua de fibras de colágeno para dispositivos médicos

Resumen

Tipo:
Búsqueda de socios
Referencia:
RDUK20150903001
Publicado:
04/09/2015
Resumen:
Una universidad británica está preparando una propuesta para la iniciativa piloto FTI del programa H2020 con el fin de mejorar un sistema de extrusión con capacidad para producir fibras de colágeno de alta calidad destinadas a una amplia variedad de aplicaciones, incluyendo tendones autólogos y sintéticos. Se buscan empresas con experiencia en producción/procesamiento de colágeno, sutura de productos de colágeno para su aplicación en el sector de dispositivos médicos y verificación de los descubrimientos iniciales en términos de compatibilidad y adhesión celular.

Details

Tittle:
H2020 FTI Pilot 2015-1: Continuous production of collagen fibres for medical device applications
Summary:
A UK university is working on an H2020 FTI pilot project proposal to scale up a unique extrusion system with the capability of producing high quality continuous collagen fibres for a number of applications including autologous and synthetic tendons. Companies are sought with expertise in collagen manufacturing/processing, weaving/knitting or braiding continuous collagen items applicable within medical device and verification of initial findings in terms of compatibility and cell adhesion.
Description:
Most people suffer from some kind of tendon injury throughout their lives. Young children, people over the age of 50 and a large number of athletes are particularly vulnerable to this type of injury. Recovery can take a very long time and repaired tendon is never as good the original untainted tendon. Autologous and synthetic tendons have not been entirely satisfactory. Collagen type I is identified as being most suitable for such types of repair provided that they can be produced as uniform, strong and continuous fibres. To date various attempts have been made to make textile-like fibres from regenerated type I collagen with limited success. The challenge therefore, has been to produce continuous collagen fibres with all the positive attributes to push this technology forward. This has been now achieved by a UK university. A unique extrusion system has been designed and built with the capability of producing high quality continuous collagen fibres with all the required attributes. Furthermore, the fibres have been subjected to an array of crosslinking treatments to compare and contrast physical strengths of the fibres as well as their propensity to allow cell growth on the fibres. A particular crosslinker has been identified as being most suitable both in terms of fibre strengthening and as well as being most preferred by living cells for adhesion and growth along fibre length.

Project objectives
- Scale up the extrusion system to allow larger quantities of fibres to be produced within any one-operation i.e. larger syringe mechanism for delivery of raw collagen as well as larger spinnerets;
- Produce multifilament fibres as well as hollow or other varieties of the fibres;
- Assess feasibility of blending collagen with other naturally based compounds/materials to enhance functional properties or to impose other biological/antimicrobial properties;
- Convert these fibres into yarn and characterize them for mechanical strength/elasticity, biological endurance/compatibility etc;
- Convert the yarns into knitted/woven or braided structures and assess their physic-chemical properties, dimensional stability/endurance etc;
- Assess their suitability in vitro studies for tissue engineering, scaffolding, wound dressings and composites for selected body-part applications;
- To plan for in vivo application leading on to commercialization.

Potential partners (companies) are sought with expertise in collagen manufacturing/processing, weaving/knitting or braiding continuous collagen items applicable within medical device and verification of initial findings in terms of compatibility and cell adhesion.

EOI Deadline 1st Nov 2015
Call Deadline 1st Dec 2015

Partner sought

Partner Sought:
- A company who is in the business of collagen manufacturing/processing or indeed similar areas who have an interest into moving into continuous collagen fibre production and have the ability to be versatile, have in-house technical/professional ability to scale up production hardware/process from a working prototype version currently available at the University; - A company with capabilities of weaving/knitting or braiding continuous collagen items applicable within medical device arena with in-house sterilization/clean room facilities; - A company that would be able to verify initial findings in terms of compatibility, cell adhesion, cell growth under various circumstances and simulated in vitro conditions with potentials to conduct in vivo trials with the finished products;
Type of Partnership Considered:
RDR

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English

Dissemination

Programme-call