Con esta herramienta te facilitamos un acceso a todas las ofertas y demandas de tecnología europeas y a búsquedas de socios para participar en propuestas europeas de I+D publicadas en la red Enterprise Europe Network, pudiendo filtrar los resultados para facilitar las búsquedas más acordes con tus necesidades.

¿Quieres recibir estos listados de oportunidades de colaboración en tu correo de forma periódica y personalizada? Date de alta en nuestro Boletín

Para optimizar los resultados de la búsqueda, se recomienda utilizar términos en inglés.

Horizon 2020: FET Open Challenging Current Thinking - consortium seeks SME in the area of surface transducers and metallic nanostructures

Resumen

Tipo:
Búsqueda de socios
Referencia:
RDIT20200115001
Publicado:
28/02/2020
Caducidad:
15/03/2020
Resumen:
An Italian research centre will coordinate a FET Open in the field of DNA manipulation and exploitation for sensing technology and biomarkers detection/identification. SMEs are required with experience in R-Y-D in field of sensor surface development nanostructuration and coating, as well as in machine learning, mechatronic and prototyping enable to manage the quality and quantity of produced data. Partners will lead the experimental development and validation stage under standard conditions.

Details

Tittle:
Horizon 2020: FET Open Challenging Current Thinking - consortium seeks SME in the area of surface transducers and metallic nanostructures
Summary:
An Italian research centre will coordinate a FET Open in the field of DNA manipulation and exploitation for sensing technology and biomarkers detection/identification. SMEs are required with experience in R-Y-D in field of sensor surface development nanostructuration and coating, as well as in machine learning, mechatronic and prototyping enable to manage the quality and quantity of produced data. Partners will lead the experimental development and validation stage under standard conditions.
Description:
Among the cutting edge of diagnostic technologies, many are based on DNA manipulation for building nano-scaffolds utilizing physical techniques to induce different conformation. Cutting edge quantum technologies are currently being used in the areas of communications, computing, and sensing. This project aims to explore the application of biology to produce DNA structures for biomarkers discovery. The research Institute is currently studying the DNA conformation induced by mesophilic and thermophilic topoisomerases enable to trigger the formation of specific DNA structures covering the full spectrum of biologically relevant topologies relevant for biological applications.
DNA topology modulation, based on conformational changes in the supercoiling state, influences the surface charge density and optical properties of the DNA scaffold, induced by enzymatic activity of selected topoisomerases. The presence on a metallic electrode of either negative or positive supercoiling states DNA, deposed on a gold electrode, leads to a difference of the average potential at the DNA scaffold/Au interface when interact with the target analyte, and an average potential variation which is proportional to the concentration of the supercoiling states DNA on the metallic surface, leading to multi-level electrical signal detection to reach a single molecule level.
Within the project the research Institute would like to explore the different DNA topologies and their different electrochemical and optical properties as scaffolds carrying a specific sequence complementary to a selected target (e.g. micro-RNA associated to cancers, heart conditions, or neurological diseases) for biomarkers discovery and early diagnosis of determined pathology states.
The proposal is being prepared for the next FET OPEN call (Horizon 2020: FET-Open Challenging Current Thinking, deadline 13 May 2020) by an international consortium represented by an academic institution,a research centre and small industries that combine basic and applied research.
Missing partners are SMEs with experience in sensor surface development nanostructuration and coating, as well as in machine learning, mechatronic and prototyping. They will participate in the development and validation stage under standard conditions of sensing surfaces and the prototyping stage, providing expert advice during the theoretical and the experimental stages.
Advantages and Innovations:
DNA manipulation method relies on biomolecular processes avoiding the use of complex instrumentation to induce specific molecular conformations. This method allows the mass-production of different species with a wide range of applications such as the biomarkers discovery, and early stage identification.
Stage of Development:
Concept stage
IPR Status:
Secret Know-how
Comments Regarding IPR Status:
The EPO search report did find methods based on the proposed technology

Partner sought

Partner Sought:
The consortium is seeking SME partners to participate in the development and validation stage under standard conditions of sensing surfaces and the prototyping stage, providing expert advice during the theoretical and the experimental stages.
Type of Partnership Considered:
RDR

Client

Type and Size of Client:
R-Y-D Institution
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Italian

Dissemination

Programme-call

Framwork Programme:
Future and Emerging Technologies
Evaluation Scheme:
Programme: H2020-FETOPEN-2018-2020 Type of Action: Research and Innovation action
Coordinator Required:
No
Deadline for Call:
13/05/2020