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Propuesta FETOPEN (H2020). Vesículas extracelulares naturales para nanomateriales a medida que superan a los programas actuales. Búsqueda de socios en los sectores de biotecnología, farmacia, cosmética y alimentación

Resumen

Tipo:
Búsqueda de socios
Referencia:
RDIT20170904001
Publicado:
14/09/2017
Caducidad:
14/09/2018
Resumen:
Un grupo de investigación italiano especializado en tratamiento con vesículas extracelulares busca socios con el fin de presentar una propuesta a la convocatoria FETOPEN-01-2016-2017 del programa H2020. El objetivo es aislar y funcionalizar vesículas extracelulares y abrir una ruta para su explotación como productos a medida en los campos de nanomedicina, cosmética y nutracéutica. La fecha límite de la convocatoria es el 27 de septiembre de 2017 y el plazo para presentar expresiones de interés finaliza el 18 de septiembre.

Details

Tittle:
FETOPEN proposal for H2020: Nature-derived extracellular vesicles for tailor-made nanomaterials beyond current programmes :- looking for partners on biotech, pharmaceutics, cosmetic, food sectors
Summary:
An Italian research group skilled in Extracellular Vesicles (EVs) treatment is looking for partners applying to H2020 FET Open - EU Call FETOPEN-01-2016-2017. The project aims for the isolation and functionalization of EVs, opening a route for their exploitation as tailor-made products in the fields of nanomedicine, cosmetics, and nutraceutics.
Description:
The project, which will be called Ves4us, will attract the interest of companies operating in related sectors of biotechnology, pharmaceutics, and the food industry. Different stakeholders will be enrolled to participate in the evaluation of natural, derivatized and loaded nanovesicles and rapidly emerging fields of basic and applied Extracellular vesicle (EV) research that will significantly profit from the innovation which may influence the biomedical landscape in the future. Extracellular vesicles (EVs) are cell-derived, membranous nanoparticles that mediate intercellular communication by transferring biomolecules, including proteins and RNA (Ribonucleic acid), between cells. Inter-species communication via EVs is a promising research field not only in basic sciences but also for the various exploitation routes they open. The discovery of EVs as natural carriers of functional small molecules and proteins has raised great interest in the drug delivery field, as it may be possible to harness these vesicles for therapeutic delivery of miRNA (microRNA), siRNA (short interference RNA), mRNA (messenger RNA), lncRNA (long non coding RNA), peptides, and synthetic drugs. Targeted EVs can be obtained by displaying targeting molecules, such as peptides or antibody fragments recognizing target antigens, on the outer surface of EVs. Display of glycosylphosphatidylinositol (GPI)-anchored nanobodies on EVs is a novel technique that will enable EVs to display a variety of proteins including antibodies, reporter proteins, and signaling molecules. Native and drug-loaded mammalian cell-derived EVs (e.g.mesenchymal cell-derived EVs) have been recently realized and now they constitute a rapidly growing research interest, known as "cell-free therapy".
The Ves4us project will focus on vesicles (e.g. exosomes) isolated from natural sources with the aim to develop a novel technology for their efficient and high-throughput isolation that will facilitate their exploitation and promotion in the fields of nanomedicine, cosmetics, and nutraceutics. The use of natural source-derived phospholipid membrane extracellular vesicles as a novel nanocarrier would be an innovative tool to enrich for valued substances and to be used as a nanocarrier vehicle.
Ves4us´ main result will be to obtain novel information concerning the chemical and physical characteristics of EVs isolated from natural sources; their bioactivity, stability and bioavailability. Physicochemical and biochemical properties of EVs will be used to develop, optimize, and validate innovative strategies and devices for high-throughput, cost effective, and efficient isolation from conditioned media. A prototype developed by the italian researchers will produce a sufficient amount of EVs to cover the needs of the ambitious strategy including the functionalization of the nanovesicles and the encapsulation of new generation drugs and nutraceuticals. The deadline of H2020 FET Open - EU Call FETOPEN-01-2016-2017 is 2017-09-27, the EOI deadline is 2017-09-18.
Advantages and Innovations:
Overall, based on preliminary results in isolating and characterizing EVs from different cell sources, a new integrated R-Y-D activity is proposed combining multi and interdisciplinary expertise through EVs chemistry and biology to nanomedicine, food sciences, engineering and social sciences. This versatile approach, which includes engineering of EV membranes for targeting purposes, is expected to allow the development of natural nanocarriers with unprecedented abilities for drug delivery in specific cells or tissues, such as, brain, lung, skin, dendritic or tumor cells. The project is based on the belief that the rapidly emerging field of basic and applied EV research will significantly profit from the innovation. This novel knowledge would then influence the biomedical landscape in the future.
Stage of Development:
Proposal under development
Technical Specification or Expertise Sought:
The project, Ves4US, will attract the interest of companies operating in related sectors of biotechnology, pharmaceutics, cosmetics, and the food industry. Indeed, different stakeholders will be enrolled to participate to be part of the Industrial Advisory Board (IAB) of the researcher group. The role of this board will be to support the Ves4US consortium in developing a research market driven on natural, derivatized and loaded nature-derived nanovesicles, where the market and the adopters´ requirements are considered from the initial research stages.
IPR Status:
Copyright

Partner sought

Partner Sought:
The partners sought are companies operating in related sectors of biotechnology, pharmaceutics, cosmetics, and the food industry with a good client network for a future commercalization of the technology. Furthermore, different stakeholders will be enrolled to participate to be part of the Industrial Advisory Board (IAB). The role of this board will be to support the consortium in developing a research market driven on natural, derivatized and loaded nature-derived nanovesicles, where the market and the adopters´ requirements are considered from the initial research stages.
Type of Partnership Considered:
RDR

Client

Type and Size of Client:
Industry 250-499
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Italian

Dissemination

Programme-call

Evaluation Scheme:
Research and Innovation Action
Anticipated Project Budget:
3.000.000 Euro
Coordinator Required:
No
Deadline for Call:
27/09/2017
Project Duration:
156
Project title and Acronym:
Ves4us: Nature-derived extracellular vesicles for tailor-made nanomaterials