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Subvención de un año para una beca de investigación. Búsqueda de empresas que fabriquen kits de diagnóstico

Resumen

Tipo:
Búsqueda de socios
Referencia:
RDIT20161206001
Publicado:
17/03/2017
Caducidad:
19/12/2017
Resumen:
Un grupo de investigación italiano ha desarrollado experiencia en la producción biotecnológica de polipéptidos similares a la elastina humana (HELPS). El grupo de investigación busca colaboración en materia de investigación con empresas especializadas en herramientas de diagnóstico innovadoras para investigación médica y clínica, concretamente empresas que fabriquen y comercialicen kits de diagnóstico para detección e investigación. El objetivo es solicitar una subvención regional para desarrollar conjuntamente los resultados de investigación y financiar una beca de investigación durante un año.

Details

Tittle:
One year research fellowship grant - Looking for companies producing diagnostic kits
Summary:
An Italian research group has developed the expertise in biotechnological production of Human Elastine-Like Polypeptides (HELPS). They are looking for research collaborations with companies focused on innovative diagnostic tools for medical and clinical research. In particular, companies producing and commercializing diagnostic kits for screening and research. A regional grant can support the co-development of the research results by paying the costs of one year research fellowship.
Description:
In the lab the research group has set up the production of a highly reproducible and easy to standardize biomimetic elastin biomaterial, produced by biotechnological methodology. This material can take on the characteristics of a hydrogel matrix that is selectively degraded in the presence of elastolytic activity. This 3D set up allows the detection of elastolytic activity and can be used to produce diagnostic devices useful to monitor different conditions where this specific proteolytic activity is present and indicates the presence of a pathologic state as infection, inflammation and so on. As examples, this system is suitable for the screening of clinical isolates of P. aeruginosa, as well as to detect or monitor latent inflammatory diseases of different origin. Moreover, a future advancement can be represented by the development of smart devices based on this material that release a therapeutic compound in the site of infection or inflammation, exploiting the elastolytic stimulus. Last but not least, this system represents a new biomimetic tool to investigate if, how and to what extent the presence of elastolytic activity due to infections or inflammation can affect the elastic tissue integrity. The research group is looking for research collaboration with companies interested in applying the system to diagnostic kits. There is a regional grant that could pay for a one year fellowship to co-develop the system if there is a collaboration research-industry ongoing. Deadline of this regional call is the end of May, 2017 so the expressions of interest should arrive before the 10th of April.
Advantages and Innovations:
The search for substrates (that allow quick and specific identification of the elastolytic activity and of its capability to degrade human tissue elastin) represents an approach directed to the improvement of the evaluation of the risk of elastin tissue damage in several pathologic conditions.
The currently used substrates to detect elastolytic activity are based on proteins such as casein and gelatin that are not correlated with elastin or are based on the bovine homologue.
The HELP 3D system mimic human elastin and is suitable for exoproteolytic activity detection.
The HELP 3D biomimetic system properly resembles the behavior of tissue elastin in vivo, allowing a reliable detection of the elastolytic activity compared to the currently used commercial substrates as, for example, elastin-congo red, that resulted more susceptible to the attack of the bacterial exoproteases.
This is due to the feature of the HELP 3D system that better mimic the hydrophobic and extensively cross-linked nature of the intact tissue elastin and its high stability and resistance to proteolytic degradation.
This biomimetic system represents a relevant option to evidence isolates endowed with potential for elastin tissue damage.
As well, this biomimetic system is very useful to better elucidate the mechanism of injury of elastin in tissues.
HELP matrix represents indeed an interesting choice to analyze and study the elastolytic activity in vitro, using standard equipment and low-cost reagents.
Stage of Development:
Under development/lab tested
IPR Status:
Patents granted
Comments Regarding IPR Status:
EU

Partner sought

Partner Sought:
An expression of interest and both technical and industrial cooperation with SMEs and companies interested in application, development or commercialization of products based on our biomimetic tools are sought. In particular, companies interested in development and commercialization of -diagnostic kits for screening and research - medical devices for smart release A regional grant can support the co-development of the research results by paying the costs of a one year research fellowship.
Type of Partnership Considered:
RDR

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Italian

Dissemination

Programme-call

Evaluation Scheme:
Deadline of the call: 31st of May, 2017. Deadline for EoIs: 10th of April
Coordinator Required:
No
Deadline for Call:
31/05/2017
Project Duration:
0