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3D Matrices for in vitro growth of tumor tissues

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOIT20201218001
Publicado:
28/12/2020
Caducidad:
29/12/2021
Resumen:
An Italian public University has developed and patented novel 3D Matrices for in vitro growth of tumor tissues in order to create a reliable in vitro experimental set-up that can reduce the number of animals in vivo experimentation. The University is looking for industrial partners interested in commercial agreement with technical assistance to support the commercialisation of the innovation or in licensing agreement. Technical agreement is also sought.

Details

Tittle:
3D Matrices for in vitro growth of tumor tissues
Summary:
An Italian public University has developed and patented novel 3D Matrices for in vitro growth of tumor tissues in order to create a reliable in vitro experimental set-up that can reduce the number of animals in vivo experimentation. The University is looking for industrial partners interested in commercial agreement with technical assistance to support the commercialisation of the innovation or in licensing agreement. Technical agreement is also sought.
Description:
The University, based in North Italy, has developed a 3D Matrices for in vitro growth of tumor tissues.
The invention proposes a 3D macroscopic myxoid matrix for cell culture that would mimic the in vivo environment of myxoid stroma tumors. The myxoid stroma consists of abundant basic substances with large amounts of glycosaminoglycans (hyaluronic acid) and proteoglycans, poor collagen fibers and no elastin content. In the proposed approach, tumor cells seeded on 3D scaffolds mimic of myxoid stroma can experience both cell-cell and cell-matrix 3D interactions as in natural tissues. The proposed myxoid stroma scaffold (i.e. support to create an in vitro three-dimensional tissue) induces cell proliferation and shows spontaneous deposition of cell own matrix.
The invention can be applied to:
1. evaluate the effectiveness of anti-neoplastic drugs
2. develop electroporation protocol for clinical treatments
3. study the cellular mechanisms at the basis of cancer
Thus speeding up the arrival to the clinical trials and avoiding the sacrifice of animals with ethical and economic advantages.

The matrix will be used in further investigations as new scaffold for cell cultures.

The Italian University is looking for companies in the biotech sector to establish license or commercial agreements with technical assistance. The aim of this collaboration will be to commercialize the innovation.
The researchers are still engaged in further development of the innovation so technical cooperation agreement with industrial partners to expand the potential applications of the innovation is also welcome.
Advantages and Innovations:
The main advantages of the proposed invention are:
1. The novel scaffold is used at room temperature and storage at +4°C;
2. The scaffold can be easily prepared in different size and shape (e.g. for 96, 48 or 24 wells or rectangular wells)
3. 3D cell cultures are obtained in a short time (48-72 h) with seeding procedure similar to the 2D culture.

The obtained in vitro tissue is extremely similar to the tumor tissue obtained from biopsies (breast cancer) and the cells in the 3D matrix experience cell-cell and cell-matrix interactions as in biological tissues, unlike 2D cultures.
Stage of Development:
Prototype available for demonstration
IPs:
Patents granted
CommeR Statunts Regarding IPR Status:
The invention is covered by an Italian patent and PCT.

Partner sought

Type and Role of Partner Sought:
Industrial partner in the biotech sector willing:

- to produce and commercialize the technology by a commercial agreement with technical assistance;
- to exploit directly the technology according to the license agreement;
- to further co-develop the technology by a technical agreement.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Italian

Keywords

Technology Keywords:
06006004 Biopolímeros
06001003 Citología, cancerología, oncología
06002007 Ensayos in vitro, experimentos
06001009 Terapia genética - ADN