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Adsorbentes con heparina y albúmina para hemoperfusión

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOUA20170725001
Publicado:
11/08/2017
Caducidad:
11/08/2018
Resumen:
Un centro de I+D ucraniano ofrece un nuevo hemoadsorbente con aplicación clínica que incluye una matriz inmovilizada y heparina para eliminar bilirrubina, ácidos biliares, endotoxinas bacterianas, citoquinas antiinflamatorias con tóxinas hidrofóbicas y componentes de ADN de la sangre. Este hemoadsorbente mejora la biocompatibilidad y aumenta la capacidad de adsorción de las sustancias mencionadas. El centro de investigación busca socios industriales y universidades con el fin de establecer acuerdos de cooperación en materia de investigación.

Details

Tittle:
Heparin albumin containing adsorbents for hemoperfusion
Summary:
Ukrainian R-Y-D center offers new hemoadsorbent for clinical application comprising nanostructured carbon matrix ,immobilised albumin and heparin for removal of bilirubin, bile acids, bacterial endotoxin, anti-inflammatory cytokines with hydrophobic toxins and DNA-tropic components from blood. This hemoadsorbent enhances biocompatibility and increases its adsorptive capacity towards aforementioned substances. Looking for industrial partners and universities for research cooperation.
Description:
The technology was developed in Ukrainian academic research center, which was established in 1960 and is a part of Ukrainian Academy of Sciences
Preliminary studies on development of heparin- protein-carbon adsorbent with a permeable coating demonstrated very high adsorptive capacity towards unconjugated bilirubin (more than 200 mg/g of carbon matrix) (Fig.1) that is several times higher than the capacity of state-of-the-art deligandizing hemoadsorbents. Heparin presence in the coating not only enhances biocompatibility but attaches selectivity to hemoadsorbents towards heparin (DNA) -binding proteins as anti-ss-DNA and anti-n-DNA antibodies . Selectivity of heparin containing charcoal to anti-ss-DNA AT 1.5 0.2( n=19) is significantly higher than those of uncoated charcoal 1.10.2 (n=31), idem for anti-n-DNA AT 1.60.18 (n=6) and 1.0 0.18(n=6). Albumin-heparin containing hemoadsorbents will be developed and tested in vitro, in vivo systems (preclinical studies). This adsorbent disposable in plastic columns (200 cc and 400 cc capacities) will be applied for treatment of acute and chronic hepatic insufficiencies and in cases of intoxication with hydrophobic poisons.
Looking for research centers, universities, big pharmaceutical companies for joint preclinical and clinical studies. Different collaboration options including research cooperation agreement are available depending on the partners´ expertise.
Advantages and Innovations:
Preliminary studies of adsorptive capacity towards unconjugated bilirubin of albumin-heparin containing hemoadsorbents show that it is 3-5 times higher than the best existing international analogues.
Stage of Development:
Under development/lab tested
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
Type of partner sought - research centers, universities, big pharmaceutical companies for joint preclinical and clinical studies. Different collaboration options including research cooperation agreement are available depending on the partners´ expertise.

Specific area of activity - Healthcare, pharmaceutical products, medical biomaterial.

Tasks - Research centers, universities, pharmaceutical companies for joint further development of the new coated nanostructured hemosorbent.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
French
Russian

Keywords

Technology Keywords:
06001024 Biomateriales médicos
06001012 Investigaciones médicas
02007024 Nanomaterials
02002002 Recubrimientos