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Agente de polarización de alto rendimiento para aplicaciones de polarización nuclear dinámica

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20141125001
Publicado:
10/12/2014
Caducidad:
10/12/2015
Resumen:
Un centro de investigación y una universidad españoles han desarrollado un agente polarizante muy efectivo que permite obtener soluciones de ácido pirúvico hiperpolarizadas libres de radical para mejorar el incremento de la señal de Resonancia Magnética Nuclear. Las pruebas comparativas entre el nuevo radical y los que existen en el mercado indican una importante mejora en el espectro obtenido por hiperpolarización. Se buscan socios industriales interesados en explotar el know-how actual y licenciar la patente.

Details

Tittle:
High performance polarization agent for Dynamic Nuclear Polarization applications
Summary:
A Spanish research institution together with an Spanish University have developed a very effective polarizing agent for obtaining free radical hyperpolarized pyruvic acid solutions that improve the signal enhancement of Nuclear Magnetic Resonance.

Industrial partners are being sought to exploit the existing know-how through a patent license agreement.
Description:
This is a change in the method of use of organic radicals applied in Dynamic Nuclear Polarization (DNP).

The current techniques consist of dissolving the suitable organic radical in the compound to be polarized. This solution is frozen and subsequently irradiated to achieve the polarization of the radical and, then, it is transmitted to the compound. Thus, the combination radical-compound-solvent is mixed with water and transferred to the NMR equipment to carry out the spectrum. The disadvantage of this method lies in the permanence of the radical in the mixture and the interference that it generates in the process due to its paramagnetic condition. Furthermore, the presence of solvents in the final mixture, causes difficulties in the implementation in in vivo experiments.

In order to avoid the use of solvents and removing the polarizing radical from the mixture that goes to the MNR equipment, a new organic radical has been synthetized. The new radical is a derivate from 1,3-bisdifenilen-2-phenylallyl and is soluble in pyruvic acid and water.

Comparative tests between the new radical and those from the market indicate a significant improvement in the spectrum obtained by hyperpolarization.
Advantages and Innovations:
· The use of vitrifying agents is not necessary.
· Radical rapid dissolution.
· Higher level of polarization.
· Polarization time is reduced.
· Substantial increase in the resulting signal.
· Stages of the reaction purified by precipitation.
· Uses: DNP polarizing agent; potential application for in vivo experiments.
Stage of Development:
Available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Spanish patent applied for with possible international protection.

Partner sought

Type and Role of Partner Sought:
Industrial partners are being sought to exploit the existing know-how through a patent license agreement.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06001005 Diagnósticos, diagnosis