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Alternativa a los anticuerpos: diseño de herramientas basadas en aptámeros para realizar ensayos rápidos con fines de diagnóstico, analíticos y terapéuticos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOFR20190718001
Publicado:
25/09/2019
Caducidad:
25/09/2020
Resumen:
Una start-up francesa ofrece una nueva generación de biosensores basados en aptámeros para realizar ensayos rápidos como alternativa a los anticuerpos. Estas herramientas basadas en aptámeros permiten dirigir, detectar, cuantificar o capturar especies químicas o biológicas (biomarcadores, metabolitos, medicamentos, contaminantes, virus, células, etc.) de interés en los campos de ciencias de la salud, farmacia, seguridad agroalimentaria y medioambiente. Los aptámeros son una alternativa a los anticuerpos monoclonales como sondas de diagnóstico, herramientas analíticas o agentes terapéuticos. La empresa está interesada en entrar en el mercado japonés y busca socios con el fin de establecer acuerdos de cooperación técnica.

Details

Tittle:
Alternative to antibodies: design of aptamer-based tools used for rapid tests for diagnostic, analytical and therapeutic purposes
Summary:
A start up based in the South-West of France offers a new generation of aptamers-based bio-sensors for rapid tests as alternative to antibodies, with reduced costs, shortened procedure, ensured sourcing. Such aptamers-based tools allow targeting, detecting, quantitating or capturing chemical or biological species of interest in the fields of health sciences, pharma, agri-food safety and environment. The French SME aims at entering the Japanese market. A technical cooperation agreement is sought.
Description:
Co-founded in 2016 by 2 PhD biologists with over 26 years experience in the sector, the French start-up develops some products in the field of the biotechnology. Its main activity is dedicated to the selection and the characterization of custom aptamers, which are some synthetic oligonucleotides. Very few companies at world level, can develop aptamer-based tools, in this emerging market.
The French start-up that employs engineers, already deals with foreign partners. 50 % of the company´s turnover comes from international sales. It also develops collaborative projects with clients such as academic laboratories or R-Y-D companies widespread internationally.


Aptamers bind with high affinity to targets of therapeutic interest: small organic molecules, proteins, virus, cells, etc. They represent an alternative to monoclonal antibodies as diagnostic probes, analytical tools or therapeutic agents. In this way, aptamer-based tools allow a rapid detection, quantification or a capture of chemical or biological species as biomarkers, metabolites, drugs, pollutants, virus, cells, ...

Aptamers used by biologists to perform experiments in drug discovery, can be produced by the French start-up:
- a first generation aptamers that are commonly applied, which are selected through the standard SELEX process (Systematic Evolution of Ligands by Exponential Enrichment process),
- a new generation aptamers for small molecules identified through the French start-up´s proprietary technology.

The aptamer-based tools obtained with the French SME method show the advantages of so-called "chemical antibodies" i.e. a strong affinity for their cognate ligand and a high specificity of recognition.

The French start-up proposes technical cooperation agreement which allows custom solution to his client :
- co-design custom aptamer-based tools with his clients,
- to design the aptamer based tool as a subcontractor offering a solution for his client
- custom turnkey products tools, as well.

The company would like to expand its activity in Asia, especially with Japanese partners, where a very few companies are operating in the field of diagnostic or analytical aptamer-based tools. He is looking for clients and partners (R-Y-D private or public laboratories but also R-Y-D companies) to co-design, step by step, the custom technical solution that will exactly meet their needs or those of their final clients.
Advantages and Innovations:
Advantages of using aptamers rather than antibodies: the in-vitro process for aptamers selection and their easy production allows non-equivalent benefits: no biological material required for the selection process (Good Manufacturing Process with less constraint), specificity control, no batch to batch variation of activity, shortened procedure, ensured sourcing, stability over a long term, large scale production, reduced production costs, wide variety of chemical modifications, easy storage and transport, no cold chain required.

Even if a few Japanese companies are active on the therapeutic function of aptamers, no company currently develops, diagnostic or analytical aptamer-based tools.
Stage of Development:
Already on the market
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
The French start up is looking for Japanese partners in the fields of pharma, food and nutrition, environment, chemical industry or cosmetic industry:
- R-Y-D/innovation departments of companies or private laboratories,
- R-Y-D academic laboratories.

The partner(s) sought should be open to co-development and will contribute actively to the technical cooperation, preferably over the long-term, to co-design the products meeting his (their) needs or their clients´ requirements.

The Japanese partner(s) will benefit from the experience of the French company and its innovative developments to enlarge his (their) catalogue(s) of products and services and meet new market targets (R-Y-D/innovation departments of companies or private laboratories) or increase technological knowledge aiming to boost projects or initiate new projects (academic laboratories).

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
French

Dissemination

Restrict dissemination to specific countries:
Japan

Keywords

Technology Keywords:
06002002 Biología celular y molecular
06002006 Biología sintética
06002001 Bioquímica / biofísica
06002009 Diseño molecular
06002003 Tecnología de enzimas