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Análisis de imágenes obtenidas por tomografía de coherencia óptica de alta definición (HD-OCT) para aplicaciones en dermatología

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOSG20160928003
Publicado:
03/11/2017
Caducidad:
03/11/2018
Resumen:
Un hospital de Singapur ha desarrollado un sistema para analizar automáticamente imágenes obtenidas por tomografía de coherencia óptica de alta definición (HD-OCT) y delinear varias estructuras de la piel con fines de visualización. El sistema construye un modelo en 3D basado en las imágenes de la piel adquiridas para poder visualizar mejor las estructuras de la piel y sus posiciones relativas. Este sistema mejora el diagnóstico clínico y la capacidad de gestión de enfermedades de la piel gracias al procesamiento de imágenes inteligente. El hospital busca pymes o centros de investigación médica con el fin de establecer acuerdos de licencia o cooperación en materia de investigación.

Details

Tittle:
Analysis of skin High Definition - Optical Coherence Tomography (HD-OCT) images for dermatological applications
Summary:
A Singapore hospital has developed a system which will automatically analyse High Definition - Optical Coherence Tomography (HD-OCT) obtained images and delineate various skin structures. This greatly enhance clinical diagnostic and management capability of skin diseases through intelligent image processing.
The organisation is interested in establishing license agreements or research cooperation agreements with SMEs of all sizes or healthcare research institutions.
Description:
Skin biopsy is the standard diagnostic procedure for skin diseases but it has many disadvantages, including pain, scarring, risk of infection, and sampling error. Thus, many patients do not consent to biopsy. The procedure is rarely performed in children. With recent advances in skin imaging technology, widespread use of imaging in clinics for practical management of skin diseases is becoming a possibility. However, images acquired are not readily interpretable.

This proposed Analysis of Skin HD-OCT IMAges (ASHIMA) system will process the HD-OCT images and automatically identified the various structures in the skin. These identified structures will then be delineated for visualization purposes. In addition, the proposed ASHIMA system will construct the 3-D model based on the acquired skin images so that the skin structures and their relative positions can be better visualised. Both delineation of structures and 3-D modelling of skin provide clinicians a more comprehensive way of examining the skin and reduce the time spent on analysis. This greatly enhance clinical diagnostic and management capability of skin diseases through intelligent image processing.

The system consists of five stages, namely Retrieval of original HD-OCT image, Pre-processing of original HD-OCT image, Structure Detection, Structure Segmentation and Indication of structures. The original HD-OCT images acquired from HD-OCT are first pre-processed to enhance the distinctiveness of the skin structures from the background. This will include methods to reduce noise such as speckle noise which are inherent artefacts in OCT-based images. At the third stage, the skin structures are identified and detected based on their characteristic features. Clinical domain knowledge will first be used to develop specific feature extractors for the targeted structures. Subsequently, the segmentation of the identified structures is carried out to obtain a delineation of the structures on the image. Lastly, the obtained structures will be labelled on the original HD-OCT images to assist clinicians for interpretation and visualization.

This technology will be applicable in both the clinical and research settings in dermatology. In the clinics, it can aid bedside diagnosis and monitoring of diseases. In research, it can be a tool to provide objective measures for the parameters under investigation.

The technology can be deployed in various modes. It can be integrated into OCT devices as a built-in system for the analysis of acquired OCT data, increasing the usability of such images. Alternatively, ASHIMA can be developed as a standalone analysis system which can be installed as a computer program and can be used individual users. ASHIMA can also be used in a service model for the analysis of skin images, where an online grading system automatically assesses images and communicates the results of the analysis back to the requestor.

The hospital is interested in establishing license agreements and research cooperation agreements with partner from the healthcare industry, such as an SME of any size to commercialise the technology, or with a research institute for further R-Y-D.
Advantages and Innovations:
Automatic identification of skin structures

- The ASHIMA system is able to identify the skin and cellular structure automatically. Currently, works have been performed on automated measurement of epidermal thickness and quantification of the skin surface topography in HD-OCT images. The technology can be incorporated into other imaging technologies to serve as a diagnosis tool.


Provides readily interpretable images for clinicians

- ASHIMA system will provide clinicians a more comprehensive OCT image with structures identified and labelled. These readily interpretable images allow clinicians to identify the abnormalities quickly and accurately. An additional feature of this system is the construction of 3D skin model. 3D model will further improve clinicians´ visualization and interpretation of the skin structures.


Time efficient

- ASHIMA system is able to provide a time-efficient diagnostic system. HD-OCT can acquire axial and en face images over a 1.8mm x 1.5mm block over 2 seconds. The rate limiting factor for the diagnosis of skin diseases is the time required by the clinician to analyse the images. With the ASHIMA system, this time is anticipated to be markedly reduced and as a result, it will allow reduction of clinic time and cost, with earlier formulation of treatment plans for skin diseases.
Stage of Development:
Prototype available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Patent is applied for Singapore

Partner sought

Type and Role of Partner Sought:
The Singapore hospital seeks to work with SMEs of all sizes or research/healthcare institutions in a licensing or research cooperation agreement partnership.

The partner sought could be a healthcare institution or healthcare technologies provider.

Under a licensing agreement:
The partner can license the technology to offer as a product or service to their customers.

Under a research cooperation agreement:
The partner can undertake joint development with the Singapore hospital to offer to introduce new products to targeted markets/segments.

Client

Type and Size of Client:
Industry >500
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English

Keywords

Technology Keywords:
01004001 Applications for Health
06001005 Diagnósticos, diagnosis
01003012 Imaging, Image Processing, Pattern Recognition
06001012 Investigaciones médicas