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Bioadhesivos fotoactivables basados en mejillón

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20170926001
Publicado:
06/11/2017
Caducidad:
06/11/2018
Resumen:
Una universidad alemana ha desarrollado un método para producir proteínas de mejillón que se activan por radiación con luz UV. Las proteínas se emplean en la producción de bioadhesivos para el tratamiento de fracturas óseas o cicatrización acelerada de heridas. La universidad busca socios del sector de biología, especialmente en las áreas de ingeniería de tejidos y cirugía, interesados en continuar con el desarrollo de la tecnología y establecer acuerdos de licencia o cooperación en materia de investigación.



Details

Tittle:
Photoactivatable, mussel-based bioadhesives
Summary:
A Berlin-based German university has developed a way to produce mussel proteins which can be activated by irradiation with UV light. Those proteins could be used in the production of bio-glues which are suitable for the treatment of bone fractures or accelerated wound healing. The university is looking for partners interested in a license or a research cooperation agreement.
Description:
In medicine, there is a long-standing demand for biocompatible glues, which can be applied for the treatment of bone fractures or accelerated wound healing. Biocompatible bio-glues must meet several demands, such as good binding strength to the tissue (adhesion), high stability under physiological wet conditions (cohesion), controllable biodegradability, no immunogenicity in the organism as well as no toxicity. However, a bio-glue that meets these demands is currently not available.

Mussel bio-adhesives are protein-based natural polymeric materials and could meet the demands mentioned above. Therefore they have the potential to revolutionize small-bone surgery and wound healing.

However, extraction of these bio-adhesives from homogenized raw-shell material, is possible, but complicated. It is expensive and results in very low yields. Chemical synthesis or biotechnological routes for simplified production of synthetic adhesive polymers with features similar to natural ones are still not feasible.

Scientists at a Berlin-based German university now found a possibility to produce mussel proteins in Escherichia coli whereby those caged proteins can be activated by simple irradiation with UV light at 365 nanometers. The advantages of such photo-protected proteins are that they allow the production of photoactivatable bio-glues, thus one can avoid the currently well-known Dopa autoxidation to Dopaquinone (a compound involved in melanin production) as this was described to negatively impair the adhesive properties of the glue.

The photoactivatable, mussel-based bioadhesives are suitable for treatment of bone fractures and wound healing.

The university is looking for partners interested in the further development of the technology. This could happen in the framework of a license agreement where the rights to exploit the technology would be transferred to the partner in return for a fee or a share of royalties.

Another way to cooperate could be a research cooperation agreement where both partners would cooperate on the further exploratory research and development of the new technology.
Advantages and Innovations:
- Synthetic production of mussel proteins
- High yield
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
European patent is pending

Partner sought

Type and Role of Partner Sought:
The university is looking for partners from the life science sector with a focus on tissue engineering and surgery for the further development of the technology. They offer a cooperation in the framework of a research cooperation agreement where both partners (e.g. industry, SME or research organisation) would cooperate on the further research and development of the process.

Another way of cooperation would be the transfer of rights involving the authorization to use the technology to a licensee (e.g. industry, SME or research organisation) who could develop a product which is ready to the market.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06002006 Biología sintética
06001024 Biomateriales médicos
06002004 Ingeniería de proteínas
06001015 Productos farmacéuticos / medicamentos