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Biosensor fotónico funcionalizado altamente sensible y de bajo coste para aplicaciones de diagnóstico médico

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOUK20151216002
Publicado:
11/01/2016
Caducidad:
11/01/2017
Resumen:
Una universidad británica ha desarrollado un biosensor de bajo coste y alta sensibilidad que utiliza un sensor CMOS económico funcionalizado para detección de enfermedades, medicina personalizada, resistencia antimicrobiana, biofouling industrial y biocorrosión. La tecnología también puede emplearse en el desarrollo de un lector de bajo coste para la detección de aflatoxinas en cultivos. La universidad busca un socio comercial con el fin de desarrollar propiedad intelectual y establecer acuerdos de cooperación técnica, investigación y licencia.


Details

Tittle:
High sensitivity, low cost functionalised photonic biosensor for medical diagnostic applications
Summary:
A UK university has invented a low cost, high sensitivity biosensor that uses a cheap CMOS sensor and can be functionalised for diseases for which antibodies are available. Applications include disease detection, personalised healthcare, antimicrobial resistance, industrial biofouling and biocorrosion. The university would like to find a commercial partner to develop new intellectual property under technical or research cooperation agreements. License agreements would also be considered.
Description:
Sensors that can detect clinically relevant concentrations of biomarkers are essential for future applications in personalised medicine and healthcare. Photonic biosensors are one of the most sensitive disease biomarker detection technologies available but a key issue is that expensive readout tools are often required which present a major hurdle towards the introduction and proliferation of the technology. High speed readout is essential, as is low cost. This invention combines high performance into a simple footprint, low cost, stand-alone device.

The sensor consists of a resonant grating which is illuminated by a semiconductor laser of fixed wavelength. The grating surface is functionalised with DNA, an antibody or an aptamer which ensures that the sensor only responds to a specific biomarker. The grating resonance shifts when the target biomarker binds to the surface and concentrations down to nanomolar level can be detected. The resulting shift is directly picked up by an imaging sensor such as a CMOS camera or a smartphone camera. The ability to pick up the resonance shift and therefore the biomarker binding event without additional instrumentation represents the unique feature of the sensor. The readout can be transmitted directly and wirelessly to a smartphone or a computer for interpretation and analysis.

The market for medical diagnostic applications (Point of care and home healthcare) is expected reach US$10bn worldwide by 2020. Personalised healthcare is a major driver and there are clear opportunities for integrating the technology with smartphone devices which would open up even larger markets.

Antimicrobial resistance (AMR) is another major application. AMR has been identified as one of the major healthcare issues of the 21st century and is expected to cost the global economy up to 3.5% of reduced GDP due to premature death. Advanced diagnostics technology will reduce the impact of antimicrobial resistance and therefore significantly reduce this cost.

Biofilm detection is another major market. Industrial biofouling and biocorrosion is estimated to cost industry over $200 billion in the US alone, suggesting that the market for detecting biofilms as a prerequisite to prevention could be valued in the range of hundreds of millions to billions of US dollars.

The technology may also be used in the development of a low cost reader for detection of aflatoxins in crops.

This UK university is interested in exploring possible partnerships with the above mentioned sectors and in developing new intellectual property under research or technical cooperation agreements. They would also consider licensing of the technology.
Advantages and Innovations:
- High sensitivity
- Low cost CMOS biosensor (cheap or possible smartphone use)
- Can be used with a wide range of diseases
- Wide range of applications
- Excellent market opportunities

Stage of Development:
Available for demonstration
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
Type of partner sought - small or large companies

Specific area of activity of the partner - photonic biosensors, medical diagnostics, industrial diagnostics, agricultural diagnostics

Task to be performed by the partner sought - Evaluate possibilities and consider partnering opportunity

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06001005 Diagnósticos, diagnosis
06004 Micro y nanotecnología relacionada con las ciencias biológicas
06005002 Sensores y productos inalámbricos
06001013 Tecnología médica / ingeniería biomédica
06001018 Virus, virología / antibióticos / bacteriología