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Biosensor MEMS integrado de radiofrecuencia multicanal

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOTR20161031010
Publicado:
23/05/2017
Caducidad:
22/05/2018
Resumen:
Un investigador ruso ha desarrollado un biosensor de microondas mecánicamente robusto fabricado con técnicas MEMS para la detección sensible, rápida y libre de etiquetas de sustancias biológicas o químicas. Este biosensor puede emplearse en diagnóstico in vitro en el punto de atención y tiene numerosas aplicaciones, desde monitorización ambiental hasta descubrimiento de fármacos, diagnóstico de enfermedades, etc. El fluido interactúa solamente en la región dieléctrica altamente sensible gracias al proceso de fabricación, que ofrece menos pérdida de radiofrecuencia y una sensibilidad total ultra elevada. El investigador busca socios con el fin de establecer acuerdos financieros.


Details

Tittle:
Microchannel integrated radio frequency MEMS biosensor
Summary:
A Turkish researcher has developed an invention which relates to a mechanically robust, microwave biosensor fabricated using MEMS techniques for highly sensitive, rapid, label-free detection of biological or chemical substances. The biosensor subjected to this invention can be used for in-vitro, point-of-care diagnostics which can have wide range of applications covering environmental monitoring, drug-discovery, disease diagnosis etc.
The researcher looks for financial agreements.
Description:
Current detection systems are based on fluorescence methods such as enzyme-linked immunoabsorbent assay (ELISA) which use labels to detect the binding of biomarkers to a biorecognition element. These method require heavy, expensive, optical devices and labeling of molecules. These bulky, costly and slow devices need a technical expert to operate and not suitable for in-vitro, Point-of-Care diagnostics which can be used for environmental monitoring or drug-discovery applications.
In this invention, the microchannel and the co-planar waveguide structure is fabricated with a novel, integrative, sacrificial-free approach using flip-chip bonding. By this way, the fluid in the channel is to be employed as the dielectric material between the signal trace and the microchannel cap which connects the ground planes like a bridge. Thus, the signal is coupled to the ground through the fluid with a coupling coefficient. This coupling creates a capacitance which depends on the dielectric properties, and so the content of the fluid. Note that this coupling mainly occurs in the region where the cap and the signal overlaps and the electromagnetic wave intensity is far higher here. Unlike many other devices in the literature, by the way of this invention the microchannel is integratedly fabricated into the RF device which eliminates extra fabrication steps, reduces cost and improves the performance providing flexibility in the design of detection region.
In this invention by a Turkish researcher, in last decades, the field of biological and chemical sensors has gone through a significant growth, mainly due to the advancements in microfabrication technologies. The developed biosensors are mainly based on optical, mechanical and low-frequency electrochemical detection. Although they are quite effective, they have some drawbacks such as the use of optical markers.


The researcher has a spin off and is currently looking for financial agreements which will provide investment for his company.
Advantages and Innovations:
The present invention differs from conventional methods in several ways.
Firstly, in this invention there is specific antibody-antigen binding events which provides the selectivity to the sensor. Thus, the sensors presented are not specific the content of the fluid. That is, the change in the s-parameters may be due to different substances in the fluid. Secondly, by the way of this invention the sensitivity is enhanced by etching ground recesses instead of using periodic structures. This approach results in much simpler and cheaper sensitivity enhancement. Lastly, the fluid in this invention interacts only in high-dielectric-sensitive region owing to the fabrication method which provides less RF loss and ultra-high overall sensitivity.
Stage of Development:
Prototype available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
PCT is pending

Partner sought

Type and Role of Partner Sought:
The researcher has a spin off and is currently looking for financial agreements which will provide investment for his company.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English

Keywords

Technology Keywords:
01001001 Automation, Robotics Control Systems
01002003 Electronic engineering
01002004 Embedded Systems and Real Time Systems
01002001 Micro and Nanotechnology related to Electronics and Microelectronics
01002007 Nanotechnologies related to electronics & microelectronics