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Biosensor para la monitorización permanente de fenoles


Oferta Tecnológica
Un equipo de investigación de una universidad polaca ha desarrollado un biosensor para la monitorización permanente de compuestos fenólicos. Este biosensor, fabricado con tecnología LTCC (low temperature co-fired ceramics), consiste en un chip microfluídico con fibras ópticas integradas y componentes optoelectrónicos y pasivos. El material LTCC es resistente a altas temperaturas y presiones. El principio de detección se basa en reacción enzimática. La concentración de compuestos fenólicos se determina según la ley de Lambert-Beer. La tecnología puede emplearse para monitorizar la concentración de fenoles en aguas residuales en protección ambiental e industria alimentaria. La universidad busca socios con el fin de establecer acuerdos de licencia.


A biosensor for permanent monitoring of phenols is offered for a license agreement.
A research team from a Polish university has developed a biosensor for permanent monitoring of phenols. It consists of microfluidic chip with integrated optical fibres, optoelectronic and passive components. It is fabricated using LTCC technology. The principle of detection is based on enzymatic reaction. The invention can be used to monitor concentration of phenols in waste water for environmental protection or in food industry. The University offers a license agreement.
An interdisciplinary research team from a Polish university from Lower Silesia has developed a biosensor for permanent monitoring of phenolic compounds.
Phenolic compounds (phenol derivatives) are a diverse group of products. On one hand phenol is toxic to the majority of micro-organisms. Due to the antiseptic properties, it is widely used as a disinfectant. Solutions of phenol irritate the skin and eyes. On the other hand, the phenolic compounds are an important class of antioxidants found in plant-based foods and their widespread occurrence in plants makes them inseparable components of food.
Phenols are detected by chromatographic, spectroscopic and other methods. Some of these techniques are expensive, with poor sensitivity and usually require time-consuming sample preparation. Moreover, these analyses may not be suitable for in situ monitoring. That is why the proposed enzyme-based sensing system is an innovative solution offering possibility for permanent monitoring of phenols. It consists of microfluidic channel chip incorporating chemo-sensitive enzymatic film (poly[2,7-bis(carbazole)-Nhexylacridone] and laccase), optical fibres, light emitting diode and photodetector. The sensor is engineered with LTCC (low temperature co-fired ceramics) technology - a well-established technique utilized in electronics, telecommunication and the automotive industry. The LTCC material is high-temperature and pressure resistant. Different 3D structures (i.e. channels, cavities) can be created inside the LTCC substrate using laser, hot embossing or mechanical milling. The LTCC technology is cost-effective and easy. The idea of the biosensor operation is based on the measurement of optical absorbance. The concentration of the phenolic compounds is determined according to the Lambert-Beer´s law.
The sensor was tested for determining the effect of the flow rate of the examined substance and the LED supply current on the sensitivity and response time. The most accurate results were obtained for low flow rate (25 ml / min). In the low flow more reactions occur, thus the measurement signal is greater and therefore the measurement accuracy is higher. Response time for measurements with the speed of 25ml / min is 5 minutes. The sensor operates repeatedly by at least 30 reaction cycles. After this time, the plate with the enzyme must be replaced.
The invention can be used among others in food industry or in environmental protection. Originally the sensor was intended for usage in monitoring the concentration of phenols in waste water.
The University is seeking for an industrial partner or R-Y-D institution with resources to develop the technology. The University offers license agreement with further technical support (if applicable). The engaged entities should be able to introduce the technology on the market. Most suitable partners for Partnership Agreement would be entities already operating in environmental protection or in food industry.
Advantages and Innovations:
· Currently available measurement methods are based on measuring phenol compounds only in the sample supplied to the laboratory. The proposed solution gives possibility to monitor phenols in real time within a few minutes thus the sensors can be implemented in production lines in food industry.
· Applicable also in in-situ monitoring of waste water.
· The research team besides license agreement offers further technical cooperation and support in a real implementation.
· The research team has a long experience in cooperation with industry.
· A possibility to extend the IP rights and apply for international patents.
Stage of Development:
Under development/lab tested
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Application for the patent was made in Polish Patent Office (UPRP) under nr P.4407585 and P.412391

Partner sought

Type and Role of Partner Sought:
Industrial entity of any type which is able to introduce the technology to the market. Preferably it operates in environmental protection or in food industry. R-Y-D department within or outside the entity with capability for further development of the technology will be useful.


Type and Size of Client:
Already Engaged in Trans-National Cooperation:
Languages Spoken:


Technology Keywords:
01001001 Automation, Robotics Control Systems
01002004 Embedded Systems and Real Time Systems
08002001 Métodos de análisis y detección
08001004 Procesado de alimentos
10004003 Reciclaje de aguas residuales