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Catalizadores heterogéneos reutilizables para reacciones multicomponente

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20161125001
Publicado:
09/12/2016
Caducidad:
09/12/2017
Resumen:
Un centro de investigación español ha desarrollado una familia de materiales metalorgánicos con estructura cristalina meso y microporosa. Esta red tridimensional permite su uso como catalizadores heterogéneos en reacciones multicomponente, por ejemplo, reacción de Strecker, de utilidad para la síntesis de aminoácidos. Las reacciones multicomponente implican el uso de varios sustratos y cuando se llevan a cabo en un solo paso, todos los reactivos se añaden al mismo tiempo. Esta metodología ofrece ventajas, como economía atómica y reducción de los pasos de purificación, pero también requiere el uso de un catalizador muy activo y selectivo. Los catalizadores heterogéneos ofrecen claras ventajas gracias a su reutilización y reciclaje. El centro de investigación busca socios de las industrias química y farmacéutica interesados en la licencia de la patente.


Details

Tittle:
Reusable heterogeneous catalysts for multicomponent reactions
Summary:
A Spanish Research Institution has developed a family of metal-organic materials with a meso- and microporous crystal structure. This three-dimensional network allows its use as heterogeneous catalysts in multicomponent reactions, for example Strecker reaction, useful for aminoacid synthesis. Industrial partners from the chemical or pharmaceutical industries are being sought to collaborate through a patent licence agreement.
Description:
Multicomponent reactions involve the use on various substrates and when done in a single step, all reactants are added at the same time. This methodology has different advantages, such as atomic economy and less purification steps, but it also requires the use of a highly active and selective catalyst. Heterogonous catalysts offer clear advantages because they are easy to reuse and recycle. One example of these catalysts are metal-organic frameworks (MOFs), which have been widely studied in the recent years due to their multiple applications. These porous crystal materials are formed by the merger of atoms or metallic aggregates through organic ligands.
Researchers have developed a family of Lewis acids heterogeneous catalyst based on Indium with the formula [In3-xMxO(BTB)2LL´]. These materials are composed by metals which belong to the XIII group, combined with two carboxylic acids and a neutral ligand. These compounds have a micro- and mesoporous three-dimensional network, improving the properties of current Indium based materials, which only have superficial activity. Its great porosity and the large size of the pores are its main advantages. These characteristics allow multiple molecules diffusion through it and accessibility to a higher number or active centres, favouring multicomponent reactions such as Strecker, fundamental in alfa-aminoacids synthesis. The great specific surface, higher than 1400m2g-1, wide number of metallic centres accessible through its pores and the high acidity of this material gives it high activity as Lewis acid.
Advantages and Innovations:
¿ High number of accessible active centres through the pores. Main pores are bigger than 2.8 nm, while micropores have a higher size than 0.3nm.
¿ The material has a specific surface larger than 1400 m2 g-1.
¿ High acidity and activity due to its structure with high density of open metal sites.
¿ Reaction yield can reach 99% using a 0.5% of catalyst. The material can be re-used at least 10 times without losing activity (yield over 90%).
¿ High structural and formulation versatility, due to possibility of modifications of metals and organic ligands used in its synthesis.
Stage of Development:
Field tested/evaluated
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Spanish patent application filed, suitable for international extension

Partner sought

Type and Role of Partner Sought:
We are searching for an industrial partner from the chemical or pharmaceutical industries to collaborate through a patent licence agreement.
The partner would use the technology for chemical synthesis at industrial scale or commercialise it.

Client

Type and Size of Client:
Industry >500
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
03004002 Inorganic Substances
05005 Micro y nanotecnología
03004006 Organic Substances