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Colágeno para regeneración ósea

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20180308002
Publicado:
26/03/2018
Caducidad:
27/03/2019
Resumen:
Una universidad alemana ha descubierto un método basado en el uso de colágeno para regeneración ósea. A diferencia de los procesos actuales de regeneración ósea, el colágeno puede aplicarse localmente. Este método permite preparar colágeno de tipo I en su estructura porosa natural. Los investigadores han descubierto que el cultivo de células madre de cornetes inferiores (ITSC) en fibras de colágeno preparadas con este método presentan diferenciación osteogénica. Por lo tanto, el método de preparación de colágeno puede emplearse en numerosas aplicaciones de medicina regenerativa, desde fracturas óseas después de accidentes hasta prótesis articular, prótesis dental o cirugía plástica. La universidad busca socios con el fin de establecer acuerdos de licencia.

Details

Tittle:
Collagen for bone regeneration
Summary:
A German university found a method to use collagen for bone regeneration. In contrast to current procedures supporting bone regeneration collagen can be applied locally. The university offers a licensing agreement to interested parties.
Description:
Destruction of bone tissue after accidents, infections or tumor therapy requires a highly orchestrated regeneration process dependent on the presence of osteoblasts forming new bone. Since native bone harbors too few osteoblasts to enable a fast recovery of acutely injured bone tissue, stem cells need to give rise to new osteoblasts directly upon fracture or surgical treatment. In this regard, mesenchymal stem cells (MSCs) are commonly described to undergo differentiation into osteogenic cells types, such as osteoblasts.

Collagen is a natural part of the bone composition, and collagen membranes are in use to support bone regeneration. However, these membranes are based on collagen, which is completely dissolved before it is further processed to a membrane, and consequently has completely lost its natural structure and consequently some important biological functions.

Researchers of a German university have found a method to prepare collagen type I in its natural pore-like structure. They have shown that cultivation of human inferior turbinate stem cells (ITSCs) on collagen fibrils prepared by that method show osteogenic differentiation. Therefore, this collagen preparation method can be used for multiple applications in regenerative medicine, e.g. in bone fractures after accidents, joint replacement, dental prosthesis, or plastic surgery.

The university is offering a license agreement. Feasible partners are companies from the regenerative medicine, prosthesis fabrication or laboratory supplier. A licensee will have to develop a product from the prototype.
Advantages and Innovations:
In contrast to current procedures supporting bone regeneration collagen can be applied locally. Soluble substances like growth stimulation factors are distributed throughout the body and possibly have an effect on not-affected parts in the body.
In addition to that this method is eligible to multiply applications in bone regeneration.
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
A European patent application was filed.

Partner sought

Type and Role of Partner Sought:
The university is offering a license agreement. Feasible partners are companies from:
- the regenerative medicine, working with stem cell therapies
- prosthesis production offering e.g. hip joints, that could be covered with the collagen
- laboratory supplier, who would offer the prepared collagen to laboratories.

A licensee will have to develop a product from the prototype. The prototype and all necessary data will be delivered by the inventors.

Licensing could include technical tasks if the production process needs to be optimized at industrial scale. Furthermore it could include joint work to optimize the technology.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06002002 Biología celular y molecular