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Consultoría en química analítica y transferencia de tecnología para mejorar y acelerar el descubrimiento de fármacos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOUK20170728001
Publicado:
31/08/2017
Caducidad:
31/08/2018
Resumen:
Una empresa británica ha creado un consorcio con el fin de cubrir una amplia variedad de recursos en química analítica para descubrimiento de fármacos. La empresa ofrece servicios de estrategia, formación, suministro y tecnología de forma integral y flexible. El consorcio cubre las siguientes áreas: asistencia en química sintética, control de calidad y certificado de análisis, ensayos de química física, ensayos in vitro de absorción, distribución, metabolismo y eliminación (ADME) y bioanálisis. Se buscan compañías farmacéuticas y biotecnológicas, así como socios de los sectores público y privado, con el fin de establecer acuerdos de servicio o comercialización con asistencia técnica.

Details

Tittle:
Analytical chemistry consultancy and technology transfer to improve and streamline drug discovery
Summary:
A UK company has built a consortium to cover a wide range of resources in analytical chemistry for drug discovery. Strategy, training, sourcing and technology transfer services can be offered not just in a very comprehensive but also very flexible way. Pharma and biotechnology companies and public-private partnerships are being sought for services or commercial agreements with technical assistance.
Description:
A UK company offers a range of consulting services aimed at improving and streamlining the use of analytical chemistry for drug discovery. Consulting services encompass the conduct of operational reviews, mitigating resource or expertise shortages with in-sourced support, training, bespoke software/automation solutions, and transfer of know-how and technology.
As far as we know, the company is the first to have established a wide consortium of smaller companies to address the need for flexibility in drug discovery services. This consortium provides a range of physical chemistry, in vivo efficacy, PK (pharmacokinetics) and bioanalytical services and know-how supported by experienced study management and consultancy, including expert DMPK (drug metabolism and pharmacokinetics) interpretation. Solutions are provided for both small and large molecule discovery.
The consortium covers the following specific areas:
· Support for synthetic chemistry
· Compound QC (quality control) and CofA (certificate of analysis)
· Physical chemistry assays
· In vitro ADME assays (absorption, distribution, metabolism, and excretion)
· Bioanalysis
Further, the company can fully support development of analytical strategy, staff resources and capital investment planning such as key equipment, methodology and technique choices for the laboratory as well as leading recruitment, on-boarding and the on-going training of personnel.
The consortium covers the full workflow including:
Laboratory Solutions
· Chromatography Applications Development
o By in-sourcing of these projects at the customer site, if possible, this will negate the need for a subsequent method transfer step. However, where necessary, they have access to a fully qualified CRO (contract research organisation) facility where all necessary laboratory work can be carried out.
· Stability and Solubility studies
· Log D measurement
· Compound QC
Compound Management
Comprehensive consultancy on strategies, systems and resources for efficient storage, tracking and retrieval of solid and solution compound collections including:
· Workflow processes from synthesis to assay designed to drive down screening cycle times
· Advice on appropriate automation strategies and instrumentation
The company´s proven experience of successfully designing, specifying and delivering highly effective software solutions for various Pharmaceutical companies allows them to offer bespoke software with features including:
· Comprehensive sample tracking
· Assay request system
o Status tracking
· Integration with analytical systems
o Open Access, QC and ADME
o Data processing and calculation
The consortium is looking to assist Pharma and biotech companies with analytical services and technology transfer support for their drug discovery programmes, including training and know-how transfer.
It is envisaged that the above solutions may be offered as a services agreement if the work is carried out inside the consortium. If the partner needs to bring some of the methods in-house, the agreement would be commercial, with technical assistance.
Advantages and Innovations:
This field is dominated by CROs (Clinical Research Organisation) who tend to be large and bureaucratic.
A consortium of small companies promises much greater speed and flexibility, whilst still covering a wide variety of methods. On top of that they help with technology transfer that CROs tend not to do.
Stage of Development:
Already on the market
IPs:
Secret Know-how,Copyright
CommeR Statunts Regarding IPR Status:
Copyright on software, secret know-how covering the whole process.

Partner sought

Type and Role of Partner Sought:
Type of partner sought - industry and public-private partnerships;
Specific activity of the partner - drug discovery;
- Task to be performed by the partner sought: industry and public-private partnerships are invited to send non-confidential description of their problems relating to either strategy or execution. The UK company can then provide a more detailed description of modules or activities that should be brought in. It will include training and know-how transfer.

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English

Keywords

Technology Keywords:
06002009 Diseño molecular
06002007 Ensayos in vitro, experimentos
06001015 Productos farmacéuticos / medicamentos
06002010 Toxicología