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Depuración óptica inocua de muestras biológicas

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20160316001
Publicado:
18/03/2016
Caducidad:
18/03/2017
Resumen:
Una universidad alemana ofrece nuevas sustancias para preparar muestras biológicas para imagen 3D. La innovación reside en el hecho de que no es necesario aplicar sustancias químicas peligrosas y que los resultados son comparables a la conservación de fluorescencia. Además es un método económico y fácil de manejar. Gracias a esta sustancia, es posible establecer un protocolo fácil de usar que permite la depuración óptica segura de muestras biológicas en microscopía, incluso por personal de laboratorio sin experiencia. La universidad busca licenciatarios industriales.

Details

Tittle:
Non-harmful optical clearing of biological samples
Summary:
A German university offers new substances to prepare biological samples for three-dimensional imaging. The innovation lies in the fact that no harmful chemicals are applied while the fluorescence preservation results remain comparable. The related method is furthermore inexpensive and easy to handle. Industrial licensees are sought.
Description:
There is currently a strongly growing need for methods and chemicals for the preparation of large biological samples for three-dimensional imaging. The latest developments in microscopy and imaging techniques (e.g. light-sheet microscopy, two-photon microscopy, optical projection tomography) facilitate the display of large three-dimensional tissue samples.

Refractive index matching of the biological sample with the surrounding medium is an established method for optical clearing of entire organs, where the key challenge, that is the preservation of fluorescence staining, has been performed already. However, all of the currently established protocols are based on the use of harmful chemicals (ref. Richardson -Y- Lichtman).

A German university now offers an invention that substitutes these harmful chemicals with a non-harmful substance with comparable results of fluorescence preservation. By means of this substance, an easy to use protocol has been established that allows a safe optical clearing of biological samples for microscopy even by unpracticed laboratory personnel.

Industrial licensees are sought for use and further development. The invented substance and protocol are of high interest for any supplier or company in the field of microscopy and imaging techniques. The unique selling proposition is that the herewith offered invention constitutes the sole methodology for optical clearing of biological samples without use of harmful chemicals combined with high quality fluorescence preservation.
Advantages and Innovations:
· First and only protocol for optical clearing that completely dispenses with harmful chemicals
· Clearing process fully preserves fluorescence-staining for high quality imaging
· Inexpensive and easy to use method
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
European patent applied for.

Partner sought

Type and Role of Partner Sought:
Industrial licensees are sought. Potential partners are active in microscopy or imaging, e.g., in pharmaceutical, diagnostic, chemical or process engineering industry.

They will have access to rights for commercial use as well as the opportunity for further co-development, e.g. of a kit.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
German

Keywords

Technology Keywords:
06002 Biología / biotecnología
01003012 Imaging, Image Processing, Pattern Recognition
06001015 Productos farmacéuticos / medicamentos
09001007 Tecnología óptica relacionada con la realización de medidas