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Desarrollo de aptámeros de alto rendimiento basados en el uso de robots de manipulación de líquidos para fines de diagnóstico y terapéuticos


Oferta Tecnológica
Una empresa británica ha desarrollado aptámeros como alternativa a los anticuerpos para fines de diagnóstico y terapéuticos. Las técnicas de producción de aptámeros empleadas utilizan robots de manipulación de líquidos que permiten el descubrimiento de múltiples aptámeros en paralelo y la incorporación posterior en modelos de diagnóstico o terapéuticos. La empresa busca socios en los campos de I+D, diagnósticos y tratamientos para establecer acuerdos de cooperación técnica.


High throughput aptamer development using liquid handling robots for diagnostic and therapeutic purposes
A UK company has developed aptamers as an alternative technology to antibodies in diagnostic and therapeutic situations. The aptamer production techniques used involves the use of liquid handling robots allowing discovery of multiple aptamers in parallel and subsequent incorporation into diagnostics or therapeutic models. The company is looking for partners with an interest in R-Y-D, diagnostics and/or therapeutics for technical cooperation agreements.
Antibodies are widely used across the life sciences. Their high affinity to a ligand enables them to be used in a range of different applications, including ELISA, detection reagents and as therapeutics such as antibody-drug conjugates (ADCs). However, antibodies have several flaws, including poor specificity, immunogenicity and reliance on biological systems for production. Importantly, aptamers are unique in their ability to bind to a much larger range of targets, from small compounds up to microorganisms and tissue extracts. Aptamers have been reported as a solution to the antibody problem and have become increasingly popular over the last decade.

This UK based company which offers bespoke aptamer design has developed a robotic liquid handling system to automate the procedure. This offers a significant advantage over the competition since it gives them the capacity to raise a greater variety of aptamers, incorporate into complex assays and allows a superior analysis for the client.

The company is looking for therapeutic and diagnostic partners who wish to develop novel aptamers for their unique requirements in the form of technical cooperation agreements.
Advantages and Innovations:
The following list outlines the main advantages of aptamers over antibodies:

- Not limited to targets that produce an immune response
- Shorter development time
- No animals used in their production
- Low batch to batch variability
- No freezing or refrigeration needed
- Longer shelf life
- No in-vivo complications relating to immune response
- Functional under a broader range of conditions
- Greater potential for specificity

The robotic handling system offers the following main advantages over and above the few competing companies that there are:

- Multiple aptamers can be handled per situation using a range of different buffers and conditions
- A more complete analysis for the client - aptamers can be tested internally via comprehensive biophysical and biochemical/cellular assays
- A faster, more reproducible service than other aptamer companies and antibody producers
Stage of Development:
Already on the market
Secret Know-how

Partner sought

Type and Role of Partner Sought:
Type of partner sought - SME or larger company. University or research organisation

Specific area of activity - pharmaceuticals, biotechnology, agritech, petrochemical companies

Tasks to be performed - assess suitability of technology for intended use and develop a cooperation agreement to carry out the work


Type and Size of Client:
Industry SME 11-49
Already Engaged in Trans-National Cooperation:
Languages Spoken:


Technology Keywords:
06001005 Diagnósticos, diagnosis
06002007 Ensayos in vitro, experimentos
06002004 Ingeniería de proteínas
06001013 Tecnología médica / ingeniería biomédica
06001009 Terapia genética - ADN