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Detección de mutaciones y modificaciones génicas

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20160616001
Publicado:
22/06/2016
Caducidad:
22/06/2017
Resumen:
Una universidad alemana ha desarrollado una plataforma que facilita la detección de supresiones e inserciones y mutaciones en genes diana a partir de una variedad de fuentes contra un elevado nivel de alelos de tipo salvaje. El ensayo puede aplicarse en cualquier laboratorio equipado con máquinas de RT-PCR. La plataforma permite la monitorización online de la respuesta al tratamiento a nivel genómico. La universidad busca organismos del sector de biotecnología roja con el fin de establecer acuerdos de licencia e investigación.

Details

Tittle:
Detection of gene modifications and mutations
Summary:
A German university developed a platform, which facilitates the detection of deletions and insertions as well as point mutations in target genes from a variety of sources against a huge background of wild type alleles. Clinicians are independent of the scarce resource tissue biopsy by using blood to detect disease relapse early and monitor treatment response. The university offers a license agreement and is open for research cooperation for organisations active in the field red biotechnology.
Description:
Particularly in oncology, determination of gene mutation statuses serves as a biomarker to guide rational therapeutic decisions. Due to patient safety sequential biopsies or biopsies of multiple tumour lesions are not routinely performed.

Scientists of a German university developed a platform, which facilitates the detection of deletions and insertions as well as point mutations in target genes from a variety of sources against a huge background of wild type alleles, making a clear "Yes" or "No" output possible and thereby simplifying therapeutic decisions.

This invention allows an easy and economical way for the stratification of patients (e.g. for treatment with tyrosine-kinase-inhibitors) with unique sensitivity. Based on realtime polymerase chain reaction (RT-PCR), the technical requirements are conventional and worldwide accessible. The non-invasive analysis of free DNA from plasma/serum samples is possible and facilitates continuous monitoring of treatment response.

Neither expensive and complicated equipment nor specialized personnel is needed. The assay is robust and applicable in all laboratories equipped with an RT-PCR machine. It can easily be established for point of care (PoC) purposes.
This technology enables clinicians to be independent of the scarce resource "tissue biopsy". By using blood (ctDNA, cfDNA or CTC) it opens new non-invasive possibilities for monitoring the mutation status of patients before and during treatment as well as to detect disease relapse early.

The German university offers a license agreement and is open for a further research cooperation with partners from industry and research involved in red biotechnology.
Advantages and Innovations:
- Compared to methods used today, the invention facilitates the detection of deletions and insertions as well as point mutations in target genes
- It can handle DNA sources from: ctDNA, CTC, biopsies, pleural effusion and bronchial lavage.
- The invention is based on RT-PCR.
- Even a high background of wild type of alleles is no problem for the platform.
- The platform allows an online monitoring of treatment response on a genomic level.
- One tumour cell/ml blood is sufficient for the gene monitoring.
- The developed platform represents a technology with a unique sensitivity. And it is fast and cost-effective.
- It is very easy to handle and produces a simple "Yes" or "No" output.
Stage of Development:
Available for demonstration
IPs:
Patents granted
CommeR Statunts Regarding IPR Status:
A European and a US patent have already been granted, other applications are pending.

Partner sought

Type and Role of Partner Sought:
The university offers a license agreement and is open for further research cooperation to further develop the platform. A potential partner should be active in the fields of red biotechnology, research tools and genetic engineering.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06002002 Biología celular y molecular
06001003 Citología, cancerología, oncología
06001005 Diagnósticos, diagnosis
06002005 Ingeniería genética