Con esta herramienta te facilitamos un acceso a todas las ofertas y demandas de tecnología europeas y a búsquedas de socios para participar en propuestas europeas de I+D publicadas en la red Enterprise Europe Network, pudiendo filtrar los resultados para facilitar las búsquedas más acordes con tus necesidades.

¿Quieres recibir estos listados de oportunidades de colaboración en tu correo de forma periódica y personalizada? Date de alta en nuestro Boletín

Para optimizar los resultados de la búsqueda, se recomienda utilizar términos en inglés.

Diagnóstico diferencial de la demencia con cuerpos de Lewy y enfermedad de Parkinson

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20160421001
Publicado:
28/04/2016
Caducidad:
28/04/2017
Resumen:
Un equipo de científicos alemanes ha desarrollado un nuevo enfoque diagnóstico para diferenciar entre la demencia con cuerpos de Lewy, enfermedad de Parkinson y otras neuropatías. La solución consiste en extraer exosomas de muestras de líquido cerebroespinal del paciente, contabilizar el número de exosomas y medir la cantidad de alfa-sinucleína exosomal. Actualmente no existe ningún ensayo ni método de imagen seguro para el diagnóstico clínico de la enfermedad de Parkinson y trastornos de parkinsonismo atípico. El equipo de científicos busca socios en el campo de diagnóstico con el fin de establecer acuerdos de comercialización y licencia.

Details

Tittle:
Differential diagnosis of dementia with Lewy bodies and Parkinson´s disease
Summary:
German scientists developed a new diagnostic approach to differentiate between Dementia with Lewy bodies (DLB), Parkinson´s disease (PD) and other neuropathies. They are looking for commercializing and licensing partners in the diagnostic field.
Description:
Parkinson´s disease (PD) is a neurodegenerative disorder affecting about 1% of the population over 65 years. Atypical Parkinson syndrome arise generally from other neurodegenerative diseases like Dementia with Lewy bodies (DLB). The accurate distinction between Parkinson´s disease, dementia with Lewy bodies and other non-alpha-synuclein variants with Parkinson syndrome is challenging due to an overlap of clinical symptoms and neuropathological changes. University scientists developed a new diagnostic approach to differentiate between DLB, PD and other neuropathies.

There is currently no assay or imaging method available that provides security for clinical diagnosis of Parkinson´s disease and atypic Parkinson syndromes. As a consequence, atypic Parkinson syndromes are often misdiagnosed as idiopathic Parkinson disease, which may lead to long-lasting mistherapy. Accordingly, there is an unmet need for methods of differential diagnosis of dementia with Lewy bodies, Parkinson´s disease and other non-alpha-synuclein variants with Parkinson-like syndromes.

The provided solution is a new developed diagnostic approach to differentiate between DLB, PD and other neuropathies by:
· extracting exosomes from cerebrospinal fluid (CSF patient samples)
· counting number of exosomes
· measuring the amount of exosomal alpha-synuclein.

Potential applications are:
· Diagnosis of PD using CSF patient samples
· Diagnosis of DLB using CSF patient samples
· Differential diagnosis DLB vs PD and/or vs other non-PD, non-dementia neurological disorders (e.g. PNP, PSP)

The scientists interested in commercialization and are looking for licensing partners in the diagnostic field (in-house diagnostics or diagnostic test kit provider).
Advantages and Innovations:
· Differential diagnosis based on sub-population of widely accepted biomarker alpha-synuclein
· Robust diagnosis due to evaluation of "shielded" alpha-synuclein in exosomes
· Use of an internal control parameter in patient´s samples (number of exosomes)
· Differential diagnosis of DLB vs PD with a high sensitivity (>0.85) and...
· ...High specificity (>0.80) - more than twice compared to CSF alpha-synuclein (total amount)
· Validated on patient´s CSF sample in a clinical cohort of >100
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
A priority patent application has been filed.

Partner sought

Type and Role of Partner Sought:
We are looking for partners active in the development and market activities in the diagnostic test market, ideally with a focus on differential diagnosis of neurodegenerative illnesses, like dementia or Parkinson´s disease.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German

Keywords

Technology Keywords:
06001005 Diagnósticos, diagnosis
06001014 Neurología, investigación cerebral