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Dispositivo para evaluar la integridad de la barrera celular mediante espectroscopía de impedancia para plataformas de cribado de nanomedicina

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20150305001
Publicado:
15/09/2015
Caducidad:
14/09/2016
Resumen:
Investigadores de un centro de investigación español han desarrollado un dispositivo para la monitorización en tiempo real de cultivos celulares presentes en modelos in vitro de barrera celular. El dispositivo se basa en medidas de resistencia eléctrica (TEER) transendotelial/epitelial y es útil en estudios de nuevos medicamentos que deben atravesar diferentes barreras celulares. Se buscan empresas interesadas en licenciar la patente y establecer acuerdos de servicio para probar nuevos medicamentos.

Details

Tittle:
Device to assess cell barrier integrity through impedance spectroscopy for nanomedicine screening platforms
Summary:
Researchers from Spanish research organisations have developed a device that allows real time monitoring of cell cultures that are present in cell barrier in-vitro models. The device is based on transendothelial /epithelial electrical resistance (TEER) measurements. This device is very useful for studies of new drugs that have to pass through different cell barriers. Companies interested in patent licensing and/or in service agreements for testing new drugs are sought.
Description:
It is known that cell barriers cultures are difficult to reproduce and particularly to monitorize when a drug is acting. The developed devicbased on a microfluidic system better reproduces the in vivo cell barrier conditions than those performed in static in vitro ones. Furthermore, the system has implemented an interdigitated electrode system for TEER monitoring that allows optical inspection techniques. The monitoring is quantitative and in real time, which facilitates the use of the device for pharmacologic assays where the control of the integrity of the cell barrier is a hallmark.
The device is easily scalable into different geometries and for using different cell types. Moreover the microfluidic system is reusable (only the culture membrane requires disposal), which minimizes the material costs for its use in laboratories.
Therefore, the device permits to closely mimic in vivo conditions, being useful for the study of different physiopathologic diseases and allowing the development and validation of therapies for their treatment.
The prototype has already been validated by using endothelial cells from the brain of a mouse.
Industrial partners in particular producesr of cell cultures equipment interested on patent license agreement are sought as well as pharmaceutical laboratories interested on cell cultures service agreement for testing new drugs.
Advantages and Innovations:
· The device allows a quantitative motorization of cell cultures by using impedance spectroscopy measurements.
· The device allows the optical monitoring of cell cultures, thus facilitating the usability of the device.
· It allows real time monitoring of barrier cell culture such as blood-brain (epithelial and endothelial) permitting the in-situ control of barrier integrity. This characteristic is very interesting for control without affecting cell physiology in the study of new drugs that should cross the barriers.
· The microfluidic design of the device includes and permits the application of a perfusion system (shear stress), indispensable for the culture of endothelial cells.
· The system is modular, dismountable and allows easy access to the cell culture chambers. This facilitates the handling and the post-experimental analysis of the different cell types.
· It also allows co-cultures of different cell types.
Stage of Development:
Prototype available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
PCT status

Partner sought

Type and Role of Partner Sought:
Producer of cell cultures equipment interested on patent license agreement.

Pharmaceutical laboratories interested on cell culture service agreement for testing drugs

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
German
Spanish

Keywords

Technology Keywords:
06001012 Investigaciones médicas