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Empresa francesa ofrece una tecnología innovadora de visualización y cuantificación de ADN

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOFR20190410001
Publicado:
17/05/2019
Caducidad:
17/05/2020
Resumen:
Una pyme francesa de biotecnología ha desarrollado una tecnología innovadora de etiquetado de ADN para generación de imágenes en tiempo real de células y organismos vivos. Esta tecnología patentada ha sido aplicada en varios campos de investigación, como generación de imágenes de alta resolución de vectores virales, cribado de compuestos y estudio de la dinámica de cromatina en células de mamíferos y levadura. La tecnología permite por primera vez visualizar y cuantificar ADN de doble cadena (dsDNA) en tiempo real. La empresa busca laboratorios académicos e industriales interesados en utilizar la tecnología. La colaboración se establecerá en el marco de un acuerdo de investigación, cooperación técnica o licencia.

Details

Tittle:
French SME offers a breakthrough technology to visualize and quantify DNA.
Summary:
A French biotechnology SME has developed an innovative DNA labelling technology for real-time imaging of living cells or organisms. This patented technology has been applied to various fields of investigation such as virus/viral vector high resolution imaging, compound screening, chromatin dynamics study in mammalian cells and yeast.
Partners sought are academic or industry labs willing to use the technology under a research or technical cooperation agreement or also a licence agreement.
Description:
French-based company has developed an innovative autofluorescent DNA labelling technology allowing for the first time to visualize and quantify double-stranded DNA (dsDNA) in real-time.
Founded in 2014, the company is a spin-off of a worldwide renowned research and development laboratory.

The offered technology has been shown to minimally affect DNA metabolism and not restricted to repetitive sequences compared to up to now labeling methods (such as FROS, TALE, CRISPR..), its high sensitivity allows single copy detection of DNA in living cells.
It can be used in different biologic models ranging from bacteria, yeast, insects, mammalian cells to viruses and viral vectors.

Applied in virology field, the autofluorescent system enables to decipher the biology of a virus, from its entry into the cell to the lysis, through the whole viral cycle. It allows to determine infection kinetics, replication and propagation of the virus, and permits to understand the mode of action of a compound in development. This technology is time efficient and delivers a quantitative and qualitative readout that standard virology techniques cannot reach up to now.

The screening of antiviral activities or oncolytic modulators of candidate drugs is then made faster and easier, and can be done on High Content or Throughput Screening platforms.
(in attachments, three examples of viruses labelled with the proprietary technology)

Used in viral vectors, the technology may be useful in gene transfer studies.
Applied in fundamental molecular biology, this technology facilitate the study of the dynamics of repair mechanisms, replication, transcription and recombination.
In developmental biology, the solution has been used in whole organism such as drosophila to follow embryogenesis.

Partners should be interested in developing a new technology to visualize dsDNA in their study model and have an interest in its applications in various fields described above.
The French company is now seeking for academic research centers and universities (under research or technical cooperation agreement), and/or pharmaceutical companies (under license agreement) depending on the partners´ expertise and project.
Advantages and Innovations:
During the five last years, the French-based SME has been awarded at a national contest for innovative companies and has been designated in its field as one of the top 10 biotech companies by an international magazine exploring technological trends in the pharma and life sciences industry.

Advantages of the technology:
- patented technology, exclusive worldwide license
- live cell imaging
- no fixation
- no extraction
- no reagents
- combinable with classical staining techniques such as immunofluorescence
- multiple (combinable) systems available for simultaneous multi-loci detection

Application areas:
- double stranded DNA
- drug candidate screening
- models: yeast, virus, bacteria,insect, mammalian cells
- chromatin dynamics
- developmental biology
- human and animal health
Stage of Development:
Already on the market
IPs:
Patents granted

Partner sought

Type and Role of Partner Sought:
The SME is looking for pharmaceutical industries and academic partners willing to use the technology for internal research.
The French company proposes a collaboration under research or technical cooperation agreements for partners such as academic research centers and universities.
A license agreement is sought for pharmaceutical companies interested.

The French company will provide its expertise, guidance and technical support to help partners to validate the technology in their specific application.

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
French

Keywords

Technology Keywords:
06002007 Ensayos in vitro, experimentos
06001015 Productos farmacéuticos / medicamentos
06001018 Virus, virología / antibióticos / bacteriología