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Empresa orientada a la tecnología ofrece un andamio polimérico en 3D con características nanométricas para investigación de cultivos celulares

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOLT20160922001
Publicado:
17/10/2016
Caducidad:
11/10/2017
Resumen:
Una pyme lituana que dispone de tecnología avanzada y experiencia en la producción de micro y submicroestructuras ha desarrollado un andamio polimérico en 3D con características nanométricas que se utiliza para el cultivo de tejidos muy parecidos a la matriz extracelular humana. El andamio consiste en pequeños poros que se imprimen en 3D a escala nanométrica y que permiten a los investigadores acceder al tejido e interactuar con él como si fuera un organismo vivo. La empresa busca socios interesados en cooperar en el campo de investigación de cultivos celulares y establecer acuerdos de investigación o cooperación técnica.

Details

Tittle:
Technology-oriented SME offers their developed 3D polymer scaffold with nanoscale features for cell culture research
Summary:
A Lithuanian SME that holds advanced technology and experience in micro and sub-micro structure production has developed a 3D polymer scaffold with nanoscale features, which can be used for cultivating tissue that closely resembles human Extra Cellular Matrix. The company is looking for partners that would be interested in cooperation in the field of cell culture research under research cooperation agreement or technical cooperation agreement.
Description:
This SME is a spin-off from a Lithuanian university and consists of staff with fundamental knowledge in the area of laser micro-machining, polymerisation and optics solutions. The company currently specializes in development and application of nano-fabrication labs and devices, which includes:
- Development of customized laser nano-fabrication laboratories, devices and device operation software
- Research and manufacturing of complex microstructures in hard transparent materials (e.g. glass) or different kinds of polymers
- Research and development of technologies for micro engraving in glasses and precious metals - marking products with micro/ nano scale quick response (QR) codes, logos and etc.

The company has currently developed a 3D polymer scaffold which can be used for cultivating synthetic tissue that closely resembles human Extra Cellular Matrix (ECM). The scaffold consists of small pores that can be 3D printed at a customized nanoscale, enabling researchers to access the tissue and interact with it as if it was in a live organism.

The scaffolds can be custom made in terms of features, shapes and sizes in order to synthesize custom ECM structures for experiments, considering specific needs of the partner.

Research or technical cooperation is sought with companies or institutions with expertise in cell culture research that would be interested in conducting research by applying ECM structures tailored to their needs - the company has all the capabilities to reproduce any ECM model from partner´s data in glass or polymers.
Advantages and Innovations:
- 3D scaffolds are bio-mimetic. The technology that the company holds allows to produce a copy of any tissue very close to Extra Cellular Matrix (ECM). ECM model, provided by partner, can be used to make 3D scaffolds directly.
- Controlled pore size. Pore size can be strictly controlled with the reproducing accuracy down to 2 micrometers. This technology allows to provide arbitrary form of cell encapsulation - particular cells can be prevented from migration (depending on the pore size).
- Non-chaotic 3D structures. This company is able to produce non-chaotic 3D scaffold structures, flexible and scalable according to partner´s requirements. Smallest feature size of scaffolds that they can produce is down to 100 nano-meters.
- Mechanically and elastically controlled bio-structure of the scaffold. This technology is able to provide advanced knitted nano-fiber structures. None of the other currently known technologies are able to generate nano-fiber knitting. Controlled mechanical properties can be reproduced in chain-mail structures (a.k.a. "knight´s armour" structures).
- Controlled hydrophilicity and hydrophobicity of the structure. Using this technology, surfaces can be made with controlled quality of water absorbance and rejection. For example, water drops on flat surface can be collected in exact locations if needed.
- Bio-decoration of 3D scaffold. By using different peptides, this technology allows to bio-decorate scaffolds if needed, making the cells move to regions of the scaffold that have better survival conditions. This allows to control the migration of cells in 3D scaffolds.
- Quick delivery. Custom scaffolds can be manufactured in short timescales - the company can materialize any structure provided by a 3D CAD file in a short time.
- Scaffolds for zero-gravity conditions. This company is able to produce special 3D scaffolds for cell self-culturing research under zero-gravity conditions for space missions.
Stage of Development:
Already on the market
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
Companies and institutions that operate in the field of cell culture research and would like to integrate the offered technology in the development of their own technologies/products are sought. The requested technical or research cooperation should focus on studies of live cell behavior for various applications.

Client

Type and Size of Client:
Industry SME 11-49
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Lithuanian

Keywords

Technology Keywords:
06002002 Biología celular y molecular
05005 Micro y nanotecnología
05003002 Óptica