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Enfoque único para estudiar la funcionalidad del sistema inmune

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOIT20180905001
Publicado:
16/10/2018
Caducidad:
17/10/2019
Resumen:
Una empresa italiana ofrece un enfoque único, sensible y específico para estudiar la funcionalidad del sistema inmune mediante las metodologías de ImmunoSPOT ligado a enzimas y precursores de alta capacidad proliferativa (PHPC). ELISpot ofrece el mejor punto de vista para monitorizar células T efectoras ex vivo, con aplicación en desarrollo de fármacos, desarrollo de vacunas y trasplantes. Este enfoque ha sido validado recientemente por la Agencia Italiana de Medicamentos. Como laboratorio acreditado para realizar ensayos inmunológicos (ensayos clínicos de fase I), la empresa está abierta a establecer acuerdos de cooperación técnica, servicio o investigación.

Details

Tittle:
Unique Approach for the Study of Immune System Funcionality
Summary:
An Italian company can provide a unique, sensitive and specific approach for the study of Immune System Functionality through Enzyme-Linked ImmunoSPOT and Precursor with High Proliferative Capacity (PHPC) methodologies; the approach has been recently validated by the Italian Drug Agency. As a laboratory certified to conduct immunology assays within the context of Phase I clinical trials, the company is open to technical cooperation agreements, service agreements or research agreements.
Description:
Within immune system functionality studies, Enzyme-Linked Immunospot (ELISpot), detects the Effector T cells cytokines secretion with an in vitro system that closely resembles the in vivo immune biology, thus allowing immune response monitoring.
ELISpot goes beyond the limits of the Eenzyme-Linked Immunosorbent Assay methodology (ELISA), that only indirectly measures cytokines, overcomes the high cell number needed for flow cytometry and, compared to Intracellular Cytokines Staining (ICS), ELISpot offers a better evaluation of the full efficiency of cytokines secretion, as intracellular staining could monitor a protein that maybe will be not released.

ELISpot offers the best point of view for ex vivo Effector T cells monitoring, with application in:
· Drug development
· Vaccine development
· Transplantation

PHPC, similarly to ELISpot, detecting the T cells cytokines secretion with an in vitro system that closely resembles the in vivo immune biology, allows immune response monitoring in many fields of immune system functionality studies.
PHPC offers the best point of view for ex vivo monitoring of Central Memory T cells, again with application in:
· Drug development
· Vaccine development
· Transplantation

Application: nowadays, ELISpot offers the best point of view for ex vivo Effector T cells monitoring, with application in:
· DRUG DEVELOPMENT: ELISpot permits to assess the immunogenicity of biotherapeutics avoiding molecules that could trigger an unwanted activation of immune system.

· VACCINE DEVELOPMENT: ELISpot permits to evaluate the immune response induced after administration of vaccine candidates.
o Cancer Vaccine (Butterfield et al. 2014)
o Infectious Disease Vaccine (Calarota et al. 2007)

· TRANSPLANTATION: Assessment of donor-specific T cell immunity pre- and post-transplant permit to identify patient with major risk of rejection and to identify immunosuppressive therapy.

The company offers its own developments in methodologies for advancements in the mentioned fields and is ready for cooperation agreements.

Advantages and Innovations:
The company was recently inserted in the list of authorized laboratory certified to conduct immunology assays within the context of Phase I clinical trials. The company can perform these immunology assays as a fee-for-service for any research center, company or university, interested in evaluating immune response in human samples deriving from drug development (e.g. immune-oncology drugs) or vaccine development programs.
Stage of Development:
Field tested/evaluated
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
The owner of the profile is looking for companies, research centers or universities willing to test immune response in human samples derived from drug development or vaccine development programs in infectious disease (viral infection or parasitic infections), oncology, transplantation programs, through Technical cooperation agreements, research cooperation agreements or service agreements.

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Italian

Keywords

Technology Keywords:
06002007 Ensayos in vitro, experimentos
06001002 Investigaciones clínicas, ensayos
06001015 Productos farmacéuticos / medicamentos