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Ensayos versátiles de tomografía computarizada con aplicación en técnicas de imagen estructural

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOHU20160707001
Publicado:
11/07/2016
Caducidad:
11/07/2017
Resumen:
Investigadores de una universidad húngara han desarrollado un método para identificar lesiones en animales anestesiados o realizar ensayos en otros preparados de forma no invasiva con la ayuda de técnicas de imagen estructural (micro-CT). El principal objetivo de este método muy preciso y versátil es explorar los procesos patofisiológicos de enfermedades dolorosas e inflamatorias de origen desconocido. El dispositivo empleado toma imágenes de rayos X en 2D y permite crear imágenes en 3D del animal con la ayuda de un software a medida. La universidad busca socios internacionales con el fin de establecer acuerdos de cooperación en materia de investigación y servicio.

Details

Tittle:
Versatile computed tomography tests with application of structural imaging techniques
Summary:
Researchers of a Hungarian university developed a method that is suitable to seek lesions on living, anesthetised animals or perform test on other preparatums in a non-invasive way with the help of structural imaging (Micro-CT). The main goal of the highly accurate and versatile method is to explore the processes of unknown origin inflammatory and painful diseases. Within the frameworks of research cooperation and service agreement they seek their international partners.
Description:
The Hungarian research group conducts discovery research. During this research they intend to explore the pathophysiological processes of the inflammatory and painful diseases. However their findings have applied research and drug development aspects as well.

They perform structural imaging (native and contrast) and quantitative analysis from which they seek bone, lung and soft tissue lesions in mouse and rat models, in living anesthetised animals, in removed organs an also in non-living preparations (material quality tests).

The micro computed tomography is a widespread three-dimensional imaging process. The device used for the tests takes 2D X-ray images, from which the 3D image of the tested animal can be created with the help of a custom software. The weakened X-ray radiation which passes over the body of the animal is converted into visible image with the help of a computer and with mathematical methods.

In case of the tomography recording, the studied object is fluoroscoped with a thin, planar X-ray beam. The detector placed behind the object senses along a line where and how much of the beam is absorbed. From the series of slice taken on a pet, the shapes with the same permeability can be highlighted. From these the spatial reconstruction of the animal can be prepared. With the injection of contrast agent, it can be achieved that the veins full of blood show bone-like images and a spatial reconstruction can also be prepared about them.

The research group created a unique pet imaging laboratory complex with a Preclinical in vivo micro CT scanner, SkyScan 1176 instrument.

The device takes computed tomography recordings of the full body of the anesthetised pets, it is also suitable for the 3D study of the virtual slides. The completion of the disease processes can be tracked in in vivo non-invasive way in the same test animals in longer terms. It is primarily suitable for structural imaging (bones, lungs).

Other possible areas of application and cooperation:
With the device and method the research group is also suitable for
- Material science tests (e.g.: analysis of rock samples)
- Planning of reconstructive surgeries based on 3D images
- Geology
- Material science
- Pharmaceutical research
- Palaeontology, anthropology - detailed tests of archaeological findings, fossils preserved in amber.

The Hungarian research group would sign a service or research cooperation agreement with those partner which are active in the above mentioned areas.
Advantages and Innovations:
Good anatomical resolution
Excellent three-dimensional information
Well-reproducible
Able to replicate the full cross-section of the body
The contrast resolution exceeds the contrast resolution of the most other imaging methods
Based on the measurement of density the certain lesions can be assigned to the different tissues
Short test time
It does not require the sacrifice of the test animals
3D imaging.
Stage of Development:
Already on the market
IPs:
Granted patent or patent application essential

Partner sought

Type and Role of Partner Sought:
The Hungarian research group seeks partners who intend to use its existing research services from the public, economic and research sector.
Those partners, who have extensive experience in the field of life sciences, especially in the field of clinical diagnostics, pharmaceutical research, geology, material sciences and even in the field of archaeology, and who would utilize the capacities of the research group.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Hungarian

Keywords

Technology Keywords:
06001005 Diagnósticos, diagnosis
06001002 Investigaciones clínicas, ensayos
06001014 Neurología, investigación cerebral
06001013 Tecnología médica / ingeniería biomédica
06001006 Vacunas humanas