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Enzyme engineering platform for development and optimization of biocatalysis for fine chemical and pharma industries

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TODE20201102001
Publicado:
09/11/2020
Caducidad:
10/11/2021
Resumen:
A proprietary enzyme engineering platform is offered by a German-Sino bio-engineering company. The R-Y-D service platform develops novel, optimized enzyme technologies with the help of bioinformatics (among others a supercomputer). It is time efficient and covers all process steps from first idea to industrial biocatalytic process. Industrial and academic partners from the fields of pharma, food, feed, fine chemicals, consumer goods and environment are sought for research cooperation agreement.

Details

Tittle:
Enzyme engineering platform for development and optimization of biocatalysis for fine chemical and pharma industries
Summary:
A proprietary enzyme engineering platform is offered by a German-Sino bio-engineering company. The R-Y-D service platform develops novel, optimized enzyme technologies with the help of bioinformatics (among others a supercomputer). It is time efficient and covers all process steps from first idea to industrial biocatalytic process. Industrial and academic partners from the fields of pharma, food, feed, fine chemicals, consumer goods and environment are sought for research cooperation agreement.
Description:
Biocatalysis is a powerful tool which allows the synthesis of almost any kind of chiral or nonchiral compound. Compared to traditional organic synthesis, enzymes reduce the necessary steps of a transformation, thereby lowering the number of intermediates which leads to less chemical waste and resource consumption. Additionally, enzymes usually work at mild, environmentally friendly conditions and are a green alternative to chemical catalysts that usually incorporate rare heavy metals and need energy consuming process conditions.

A German-Sino bio-engineering company offers a proprietary enzyme engineering platform to optimize biocatalytic transformations in industrial processes. The company offers R-Y-D service platform, guiding the customer from the initial idea all the way to the industrial biocatalytic process.

The company guides this process with an international team of highly experienced scientists applying the latest state of the art technologies. Using their comprehensive experience in directed enzyme evolution, strain engineering, fermentation process development and commercial scale biocatalytic production, they successfully apply a proprietary R-Y-D platform to develop novel, optimized enzyme technologies. This enzyme directed evolution platform is innovated by the integration of bioinformatic database guided design, computer modelling and simulations, as well as state of the art high throughput screening systems.

The platform was established in 2015 and has been successfully applied to almost 150 projects. Each process step is continuously monitored and evaluated and further developed and optimized.

It provides services for various fields of application, such as the fine chemical, food, pharmaceutical, and material industries. The development of enzymatic technology for feed, environmental and waste treatment industries is also being explored.

The company is looking for industrial and academic partners from various fields, which are either seeking new synthetic routes for specific fine, pharmaceutical and commodity chemicals or options to optimize existing processes by implementing enzymatic transformations. A research cooperation is envisaged.
The biotech company is furthermore open to other kinds of cooperation.
Advantages and Innovations:
The German-Sino bio-engineering company has developed a proprietary protein engineering platform combing computational enzyme engineering with directed evolution, resulting in several advantages:

· The combination of in silico prescreening and focused library design provides a high sequence coverage while dramatically reducing the library size and required experimental time.
· p2.0 supercomputer account allows for time efficient and parallel handling of multiple computer aided enzyme evolution projects.
· Thorough analysis with HPLC /GC (high performance liquid chromatography / gas chromatography) methods provides comprehensive reaction insights on all components of the reaction.
· Application of the desired final process conditions during the entire enzyme development allows easy transfer of the finalized process.
· The optimized, engineered enzymes are high performance catalysts that meet the requirements of each unique industrial process, from enantioselectivity to solvent stability.
· The developed enzymatic processes enable the manufacturing of a broad spectrum of optically pure products for all kinds of industries.
Stage of Development:
Already on the market
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
PCT application

Partner sought

Type and Role of Partner Sought:
The company is looking for industrial and academic partners from the fields pharma, food and feed, fine chemicals, consumer goods and others. Therefore the company provides a comprehensive enzyme technology plattform for the partner´s R-Y-D projects, e.g., for new synthetic processes towards fine and pharmaceutical
chemicals or optimization of existing processes. Hence a research cooperation is envisaged. The company is also open to other types of cooperation.

Client

Type and Size of Client:
Industry SME 50-249
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
Chinese
English
German

Keywords

Technology Keywords:
06003001 Bioinformática
06006012 Bioprocesos
06006003 Componentes bioquímicos
06002004 Ingeniería de proteínas
06002003 Tecnología de enzimas