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Expertise for high quality design of preclinical studies

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOIT20210513001
Publicado:
26/05/2021
Caducidad:
27/05/2022
Resumen:
The company is an Italian academic spinoff, founded in 2015 by a group of senior academic neuroscientists. It offers preclinical studies spanning from a wide range of behavioral tests to models of neurological injuries to cardiovascular, endocrine and metabolic measures. The company seeks industrial partners or R-Y-D centers for technical or research cooperation agreements.

Details

Tittle:
Expertise for high quality design of preclinical studies
Summary:
The company is an Italian academic spinoff, founded in 2015 by a group of senior academic neuroscientists. It offers preclinical studies spanning from a wide range of behavioral tests to models of neurological injuries to cardiovascular, endocrine and metabolic measures. The company seeks industrial partners or R-Y-D centers for technical or research cooperation agreements.
Description:
The Italian company is located in Northern Italy (Piedmont region) and provides pharmaceutical, biotechnology and medical device companies and research centres with high quality research and on-time results to prove the efficacy of new drugs in vivo, for the treatment of neurological or psychiatric disorders or biocompatibility of biomedical devices. The company has longstanding, extensive experiences in designing specialized in vivo studies and identifying new and robust models for the preclinical proof of concepts, adapting them to partners´ project needs.
In details, the company provides the following experimental solutions:
- In vivo studies: the company supplies a wide range of functional and psycho-emotional behavioural tests, neurological injury models, brain tumour models, surgical techniques with rodents as well as cardiovascular, endocrine and metabolic measures;
- Behavioural studies: psycho-emotional tests, cognitive tests, stereotypic behaviours, explorative behaviour, sociability, stress, daily activities, addiction;
- Neurological function studies: reflexes, motor coordination, sedation, ischemia, epilepsy, Huntington disease;
- Neonatal and juvenile studies: environmental effects, analysis of developmental milestones;
- Functional studies: locomotor activity, spontaneous locomotor activity, feeding behaviour, sexual behaviour, heart rate and blood pressure, oxygen saturation, breathe rate, pulse and breathe distention;
- Surgical techniques: traumatic brain Injury, acute and chronic glaucoma models, neuropathic pain, spinal cord lesions, central nervous system and in utero grafting, microsurgery, in utero electroporation, toxic transient focal or global demyelination;
- Administration routes: oral routes, parenteral routes, local routes (dermal, ocular, intranasal, intravaginal, buccal, intrarectal), adeno and retroviral injections;
- Drug exposure evaluation: bioavailability;
- Morphological and biomolecular analyses;
- Histological analyses: stereological and morphometric analyses, microscopy;
- Cellular and biomolecular analysis: cell cultures, genotyping and protein gene expression;
- Experimental models: the company can provide wild type and genetically engineered mouse models for preclinical proof of concept studies;
- Genetically modified mouse models: cerebral amyloidosis, familial Alzheimer´s disease, cerebellar ataxia, amyotrophic lateral sclerosis, spinal muscular atrophy, types A and B Niemann-Pick disease, anxiety, obesity, metabolic syndrome, transgenic mice for visualization of fluorescent neurons and glial cells, mutant lines for cell-type specific conditional and inducible knockout of target genes;
- Brain tumour models: in vivo models of glioblastoma (grafts of mouse or human glioblastoma cell lines), RI-based longitudinal analyses, histological investigations, end-point analyses.
Available facilities:
- Behavioural tests facility offer mazes and infrared camera for behavioural analysis. A computerized video-tracking system (Ethovision XT video track system) is also available;
- Neuroanatomy facility offers a confocal microscope, numerous research quality microscopes, an electron microscope and several computer-imaging systems for morphometry, autoradiography quantitative densitometry and image processing;
- Neuro-histology facilities offer sliding microtomes, rotary microtomes, vibratomes and cryostats;
- Biosafety Level 2 facilities and cellular and molecular biology facilities are also available.

The company is looking for technical or research cooperation agreements. Partners sought (pharmaceutical, biotechnology and medical device companies, Contract Research Organizations (CROs), research centres) should be interested in applying these methods for proof-of-efficacy of new drugs or pilot in vivo studies, or in further developing specific diagnostic tools as a test kit, for new fields of application, by means of technical or research cooperation agreements.
Advantages and Innovations:
The company offers preclinical studies in small animals spanning from a wide range of behavioural tests to models of neurological injuries to cardiovascular, endocrine and metabolic measures. It combines the power of a preclinical start-up to draw on scientific faculty to solve the most complex problems. The staff experience will help pharmaceutical, biotechnology, medical device companies and research centres to establish the proof-of-efficacy of new drugs or pilot in vivo studies.
The quality of the studies offered is ensured by the long-term expertise of the company´s staff, active in an internationally recognized academic research environment. Team´s knowhow covers a wide variety of multidisciplinary research activities applied to neurosciences, including neuroanatomy, neurophysiology, neuropharmacology, neuro-regenerative medicine, cellular and molecular biology. The headquarter and preclinical research unit are located within a neuroscience research centre that gathers the complementary experiences of basic and clinical research groups sharing of knowledge, expertise, capabilities and facilities. Equipment, methods and techniques are constantly improved to meet the most innovative standards, thus providing the best up-to-date solutions to research partners.
The company´s standards are based on honesty, confidentiality and integrity during the entire workflow, ensuring reliability and flexibility from the experimental design to the data collection and final report.
Stage of Development:
Already on the market
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
Pharmaceutical, biotechnology and medical device companies, Contract Research Organizations (CROs) and research centres are the target partners for the company´s technology deployment in the framework of technical / research cooperation.
The company is also open to cooperate within international research projects, thus joining directly or as an external partner, with implementing tasks.

Client

Type and Size of Client:
Industry SME <= 10
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Italian

Keywords

Technology Keywords:
06002002 Biología celular y molecular
06001016 Fisiología
06001014 Neurología, investigación cerebral