Con esta herramienta te facilitamos un acceso a todas las ofertas y demandas de tecnología europeas y a búsquedas de socios para participar en propuestas europeas de I+D publicadas en la red Enterprise Europe Network, pudiendo filtrar los resultados para facilitar las búsquedas más acordes con tus necesidades.

¿Quieres recibir estos listados de oportunidades de colaboración en tu correo de forma periódica y personalizada? Date de alta en nuestro Boletín

Para optimizar los resultados de la búsqueda, se recomienda utilizar términos en inglés.

Inhibidores de serpina para el tratamiento de enfermedades priónicas y similares

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOIT20190206002
Publicado:
01/03/2019
Caducidad:
01/03/2020
Resumen:
Un grupo de investigación italiano ha desarrollado una nueva clase de moléculas pequeñas que actúan como inhibidores de SERPINA3, capaces de reducir la acumulación de la proteína del prión (PrPSc) en líneas celulares infectadas por priones, siendo un nuevo tratamiento terapéutico contra enfermedades priónicas y similares. La caracterización de modelos estructurales de la unión de moléculas pequeñas con la proteína permite identificar nuevos inhibidores con mayor potencia. Hasta ahora no existían terapias efectivas para enfermedades priónicas. El grupo de investigación busca compañías farmacéuticas con el fin de establecer acuerdos de licencia y joint venture, así como inversores para establecer acuerdos financieros.

Details

Tittle:
Serpin inhibitors for the treatment of prion and prion like diseases - License agreements and joint venture opportunity
Summary:
A research group based in Italy has developed a new class of small molecules acting as SERPINA3 inhibitors, which are able to reduce prion protein (PrPSc) accumulation in prion-infected cell lines, thereby representing a new therapeutic treatment against prion and prion-like diseases. They are looking for licence agreements and joint venture agreements with pharma companies and/or financial agreements with investors.
Description:
To date, despite numerous active efforts, there are no drugs available for the cure of the neurodegenerative diseases collectively referred as prion and prion-like disorders. Symptomatic treatment is the only available option, including the administration to patients of antipsychotics, such as quetiapine and clonazepam, to treat myoclonus, and of selective serotonin re-uptake inhibitors (SSRIs) to treat depression.
Indeed, through this invention, the technology transfer office of a research center based in the North of Italy and internationally renowned, is presenting a new class of small molecules. These small molecules are acting as SERPINA3 inhibitors, which are able to reduce PrPSc accumulation in prion-infected cell lines, thereby representing a new therapeutic treatment against prion and prion-like diseases.
The development of specific inhibitors of SERPINA3 with an activity in the nanomolar range is expected. The characterization of structural models of the binding of the small molecules with the protein should allow the identification of novel inhibitors with improved potency.
The research center is looking for licence agreements or joint ventures with industry (pharma companies) or financial agreements with investors interested in developing new drugs.
Advantages and Innovations:
So far there are no effective therapies for prion diseases. The proposed technology aims at developing novel molecules with improved efficacy on these diseases.
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
The patent owners are: Italian Research Center 1 (50%), German Research Center (37.5%) and Italian Research Center 2 (12.5%). The European search report has shown a complete novelty and inventive step. Supplementary material and supporting data available upon request.

Partner sought

Type and Role of Partner Sought:
Pharma Companies/Investors interested in acquiring and co-developing the technology.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Italian

Keywords

Technology Keywords:
06001014 Neurología, investigación cerebral