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Kit, composiciones y preparaciones combinadas para el tratamiento de la mucositis oral y dolor orofaríngeo

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20160601002
Publicado:
22/06/2016
Caducidad:
22/06/2017
Resumen:
Un equipo de investigación español especializado en tratamiento del dolor crónico ha desarrollado una nueva composición que combina ketamina y meperidina para el tratamiento de la mucositis oral y dolor orofaríngeo asociado a terapias del cáncer. Esta nueva composición se presenta en forma de jarabe o cápsulas. El grupo de investigación busca colaboración para transferir la solución mediante acuerdos de licencia o continuar con el desarrollo mediante acuerdos de cooperación técnica.

Details

Tittle:
Kit, compositions and combined preparations for the treatment of oral mucositis and oropharyngeal pain, developed by a Spanish research group
Summary:
A Spanish research group, specialized in chronic pain treatment, has developed a new composition combining Ketamine and Meperidine for the treatment of oral mucositis and oropharyngeal pain, associated with cancer therapies. The dosage form of this new composition is presented by syrup or capsules.

The research group is seeking collaboration to transfer the solution through a license agreement, or further develop it through a technical cooperation agreement.
Description:
A Spanish research group from the Andalusian public health system, which has being working for several years in the treatment of the different stages of chronic pain, supported by two universities, has developed a new composition for the treatment of oral mucositis and oropharyngeal pain.

Erythematous and ulcerative oral mucositis is an oral complication due to cancer therapies (especially head and neck cancer), characterized by a high prevalence, high comorbidity and there is no effective treatment against it.
These oral complications are major obstacles to the treatment of cancer and the proliferation of associated infections can cause interruptions of the radiotherapy or chemotherapy treatment and, in extreme cases, can be life threatening.
Besides, the treatment of pain in oncological diseases should be considered as a priority as the underlying disease, because, the pain and uncontrolled pain crises, could become as devastating as the disease itself. For this reason, the Andalusian unit, specialized in chronic pain treatment, was working on a solution to the problem of oral mucositis and oropharyngeal pain.

The invention consists in a composition, a kit for the preparation thereof and/or a combined preparation comprising a free base or any of the pharmaceutically acceptable salts (with a free base having a certain formula) and an opioid antagonist of the peripheral mu receptors. Particularly, it is a composition of Ketamina and Meoeridina and a combined preparation between those two elements, giving as a result the solution, which can be dosed through syrup or capsules, to be used in the treatment of oral mucositis and oropharyngeal pain associated.

The research group aims to formalize a technology transfer process with entities interested in the implementation of the solution, through license agreement. If there are some entities, such as R-Y-D centers, technology centers or specialized companies, interested in collaborate and develop further aspects of the solution, a technical cooperation agreement could be envisaged.
Advantages and Innovations:
-These topical treatments have the advantage of local pain control while minimizing systemic side effects.

-This composition administered in the oral cavity for the treatment of oropharyngeal pain, has excellent results.
Stage of Development:
Field tested/evaluated
IPs:
Patents granted
CommeR Statunts Regarding IPR Status:
International patent PCT

Partner sought

Type and Role of Partner Sought:
Type of partner sought:
SMEs, companies and R-Y-D Institution


Field of activity:
Pharmacology, Oncology

Task to be performed by the partner:
-Arrangement of the condition of the license agreement and co-working for the implementation of the solution

-Co-development of further aspects of the solution and its improvement

Client

Type and Size of Client:
Other
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06001003 Citología, cancerología, oncología
06001002 Investigaciones clínicas, ensayos
06001015 Productos farmacéuticos / medicamentos