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Materiales de proteína-polímero para aplicaciones energéticas y médicas

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20190702003
Publicado:
12/07/2019
Caducidad:
12/07/2020
Resumen:
Un instituto de investigación español sin ánimo de lucro ha desarrollado una familia de revestimientos poliméricos flexibles y rígidos en los que se agregan fácilmente proteínas y enzimas fluorescentes y donde un proceso de deshidratación posterior transforma los revestimientos en un material de goma/rígido sin reticulación química. En todos los casos, la biofuncionalidad se conserva de manera sorprendente en condiciones ambientales a lo largo de los años y tras varios meses bajo condiciones de funcionamiento del dispositivo/reactor. El dispositivo tiene diversas aplicaciones: filtros de color, biodiagnóstico como alternativa a los sustratos para estabilizar compuestos, biorreactores en flujo continuo, revestimiento de concentradores solares y dispositivos médicos para tratamientos de fototerapia. El instituto de investigación busca socios en los sectores de energía inteligente, bioquímica y materiales con el fin de establecer acuerdos de licencia y cooperación en materia de investigación.

Details

Tittle:
Protein-Polymer materials for energy- and medical-related applications
Summary:
A non-profit Spanish research institute from Madrid has developed a family of both flexible and rigid polymer coatings, in which fluorescent proteins (FPs) and enzymes are easily introduced as well as a dehydration process further transform the coatings into a rubber/rigid material without chemical cross-linking. The cooperation types are license and research cooperation agreements.
Description:
The EU priority action lines state the need of low-cost production and efficient consumption of electricity, while the EU Sustainable Development Strategy Commission strongly encourages the further advance of PVs and LEDs following the "green photonics" concept: development of eco-friendly and highly stable materials for an efficient generation and use of the energy.

In this context, the use of bio-molecules as operational compounds is a major challenge. The major limitation is their quick denaturation caused by light and temperature stress under device fabrication and operation conditions. However, their distinctive ecological features, such as unlimited low-cost production using bacteria and/or fully recyclable nature, strongly encourage their use as a model of sustainability. These limitations are also noted in bio-diagnosis, phototherapy, and bio-reactors. Here, stability and access of active bio-compounds is critical, hampering the commercial jump of many approaches. In addition, the working conditions also require low temperatures and irradiations.

The problem statement relates to an urgent need for effective strategies to use biomolecules directly extracted from bacteria as functional components for developing sustainable and stable medical and energy-related technologies. This approach must ensure an excellent stability of the biofunctionality under storage and device operation conditions and the use of 3D substrates and/or miniaturization.

This Spanish research institute has developed both, a family of flexible and rigid polymer coatings, in which fluorescent proteins (FPs) and enzymes are easily introduced as well as a dehydration process further transform the coatings into a rubber/rigid material without chemical cross-linking. In all cases, the bio-functionality is surprisingly preserved over years under ambient conditions and several months under device/reactor operation conditions.

The device applications involve:
i) color filters for color down-conversion applications in lighting - LEDs replacing current IP and displays replacing toxic Cd QDs,
ii ) biodiagnosis replacing substrates to stabilize active compounds, iii) bioreactors in continuous flow ,
iv) coating for solar concentrators, and
v) medical devices for phototherapy treatments.

The research center is searching for potential partners from the intelligent energy, biochemical and materials sectors to establish license agreements, preferably industry, and research cooperation agreements also open to academic and other research organisatios.
Advantages and Innovations:
Energy-related applications: Use of color filters based on FP emitters or antennas for lighting and photovoltaic.
·Replacement of IPs in white-emitting LEDs.
·Patent-free production of FP (<0.1 $/gr, low purification level, PLQY>80%).
·High color rendering index (CRI>95) with narrow emissions (30-50 nm).
·High efficiencies higher than 100 lm/W.
·High stability of FP coatings under operation:
·Low power LEDs: >150 days to reach L50.
·High power LEDs: >10 days to reach L50.
·Easy 3D printing to develop microstructured filters for displays.
·Replacement of Cd-QDs for solar windows.
·Large Stoke-shift FPs with high PLQYs >70%.
·Long range light-guiding.
·Self-healing upon day-night cycles.
·Device efficiencies over 5%.

Medical and diagnosis applications: Use of polymers to stabilize enzymes and FPs
·Long term stability of bio-compounds (enzymes, etc.) over months under ambient conditions.
·Low detection (10-7 M depending on the type of regnant).
·Large volume of conversion (>50 mL) at low operation times (<1min).
·Efficient light-scattering for phototherapy.

Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted

Partner sought

Type and Role of Partner Sought:
The research center is searching for potential partners from the intelligent energy, biochemical and materials sectors to establish license agreements, preferably industry, and research cooperation agreements also open to academic and other research organisatios.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06006001 Biomateriales
02007023 Materiales híbridos