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Método de deposición de revestimientos bioactivos de polímero aniónico natural, especialmente alginato y hialuronato, en elementos hechos de aleación de titanio

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOPL20161118001
Publicado:
29/11/2016
Caducidad:
29/11/2017
Resumen:
Científicos polacos han desarrollado un método de deposición de un revestimiento de polímero bioactivo en componentes hechos de aleación de titanio para aplicaciones biomédicas. El incremento de la biocompatibilidad y bioactividad de los biomateriales se consigue mediante deposición electroforética de revestimientos de biopolímero (alginato y hialuronato) en su superficie. Los científicos buscan fabricantes de implantes con el fin de establecer acuerdos de licencia o fabricación o institutos de investigación para realizar ensayos in vivo.

Details

Tittle:
Deposition manner of bioactive coating of natural anionic polymer especially alginate or hyaluronate on element made of titanium alloy.
Summary:
Polish scientists have developed a method of deposition of a bioactive polymer coating on the component made of titanium alloy for biomedical applications. The increase in biocompatibility and bioactivity of biomaterials is achieved by electrophoretic deposition (EPD) of biopolymer (alginate, hyaluronate) coatings on their surface. The scientists are seeking a license and/or manufacturing agreement with an implants manufacturer, or a research institute, for in-vivo studies.
Description:
The scientiscts from Poland conducting research in the field of nanotechnology and biotechnology have developed a novel method of deposition of bioactive coating on titanium and its alloys.
Today´s medicine allows to fix every broken bone and replace the missing one. But every implantation brings the risk of implant rejections due to inflammation or for example metalosis. That is why the material for implants are so important. Titanium and its alloys with mechanical properties similar to the human bones, low weight and Young modules, biological inertness and good corrosion resistance, are excellent materials for biomedical applications. The increase in biocompatibility and bioactivity of metallic implants was achieved by electrophoretic deposition (EPD) of biopolymer (alginate, hyaluronate) coatings on their surface. The alginate is natural biodegradable polymer characterized by high biocompatibility, bio-functionality and non-toxicity. The hyaluronian exhibit a specific hydrophilic, rheological and viscoelastic properties. What is more it acts an important role in many biological processes such as embryogenesis, metabolic turnover of tissues, inflammation and wound-healing process. Both of these polymers are widely used in medical applications such as tissue engineering, drug delivery, nervous tissue repair, bone or wound dressing. Alginate and hyaluronate are anionic polymers and EPD process was conducted in anodic way where the covered substrate (implant) is the anode. The attempts to obtain alginate and hyaluronate coatings directly on the surface of titanium alloy by anaphoretic deposition did not give satisfactory results due to the presence of oxide film formed at the anode surface. Resistivity of titanium alloy at 25°C is around 1013 ¿ cm2 and the conductivity of the substrate is badly low. Therefore, the researchers have proposed in their study prior to alginate or hyaluronate deposition, to deposit cataphoretically a thin film of zinc oxide as an interlayer which improves the conductivity and results in increase of the yield of the EPD process. EPD method allows to control the thickness, microstructure and porosity of the coatings by appropriate selection of parameters and chemical composition of the electrochemical bath.
Formed coating can be utilized in DDS (drug delivery system). Obtained coatings could be saturated with broad-spectrum antibiotics, releasing from 14 to 21 days limiting the growth of bacteria and the emergence of inflammation - periimplantitis. Biopolymer coatings systems are used also in GTR, affecting the restoration of structures of periodontal tissue and alveolar bone regeneration, increasing the stability of implants.
The researchers are searching for manufacturing or license agreement with companies producing implants or other elements from titanium and its alloys.
Advantages and Innovations:
The covered materials are titanium alloys with non-toxic alloying elements (Mo, Zr, Nb) and mechanical properties similar to human bones. What is more those materials are characterized by high corrosion resistance due to presence on their surface an oxide layer of TiO2. These factors influence the conductivity of the substrates and the efficiency of the anionic polymer deposition is badly low. The proposal is to apply the inner-layer which improve the conductivity of the substrates and increase the yield of deposition process.
Electrophoretic deposition is simply process, there is no high requirements for apparatus and it is not expensive method. Great advantage of this method is no restriction to the shape of the coating object. This methods allows to control the thickness, microstructure and porosity of the coatings by appropriate selection of parameters. Formed coating can be utilized in drug delivery system - DDS. Obtained coatings could be saturated with broad-spectrum antibiotics, releasing for 14 for 21 days limiting the growth of bacteria and the emergence of inflammation - periimplantitis. Biopolymer coatings systems are used also in guided tissue regeneration - GTR, affecting the restoration of structures of periodontal tissue and alveolar bone regeneration, increasing the stability of implants.
Stage of Development:
Available for demonstration
IPs:
Granted patent or patent application essential

Partner sought

Type and Role of Partner Sought:
The researchers are searching for the company that produces implants or other company which need to cover metallic substrates with polymer coatings. They also consider to contact with the medical research institute which help in biological studies in-vitro and in-vivo of obtained biomaterials. The invention is being developed and the researchers are willing to establish a manufacturing or license agreement.

Client

Type and Size of Client:
Industry SME 11-49
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Polish

Keywords

Technology Keywords:
02007020 Biobased materials
02007010 Metals and Alloys
02007014 Plastics, Polymers
02002002 Recubrimientos
06001013 Tecnología médica / ingeniería biomédica