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Método de revestimiento de stents vasculares de titanio, válvulas cardíacas artificiales y otros dispositivos médicos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOSI20170613001
Publicado:
23/06/2017
Caducidad:
23/06/2018
Resumen:
Un instituto de investigación esloveno especializado en ingeniería de superficies ofrece una tecnología de tratamiento superficial de stents vasculares de titanio y otros dispositivos médicos. El método desarrollado reduce la adhesión y activación plaquetaria en los dispositivos médicos. Las superficies producidas se emplean en stents y válvulas cardíacas artificiales para reducir trombos en la superficie del implante. El método consiste en la nanoestructuración de la superficie de titanio mediante anodización electroquímica y exposición de la superficie nanoestructurada a átomos neutros de oxígeno para eliminar las reacciones trombóticas. El instituto busca fabricantes de stents vasculares y dispositivos médicos con el fin de establecer acuerdos de licencia o cooperación técnica.




Details

Tittle:
Method for coating titanium vascular stent, artificial heart valves and other medical devices
Summary:
A Slovenian research institute offers technology for surface treatment of titanium vascular stents and other medical devices. The developed method reduces adhesion and activation of platelets on medical devices. Surfaces produced can be used for stents and artificial heart valves in order to reduce thrombus reactions on the implant material surface. Producers of vascular stents and other medical devices are sought for licence or technical cooperation agreement.
Description:
The major cause of mortality in the modern world is coronary artery disease. The majority of percutaneous coronary interventions involve stents, which are implemented in order to help enlarge the lumen wall, restore the blood flow through the affected vessel and thus decrease the risk of a heart attack. In the blood the clumping or aggregation of platelets in the blood leads to the formation of a thrombus which obstructs the flow of blood through the circulatory system and thus leads to cardiovascular disease and increases the risk of heart attack.

There are two main types of stents: drug-eluting stents (DES) and bare metal stents (BMS). In the last few years adverse clinical data linking DES usage to arterial thrombosis had led to a large decrease in sales. Furthermore, companies are seeking to develop novel stents, while so far the improvements on DES are merely incremental. Innovations are done mostly on the polymer coatings, stent platforms and in drug components. Moreover DES are almost three to four times more expensive compared to bare metal stents (BMS).

The very promising properties of titanium and titanium alloys, specifically high biocompatibility, resistance to body fluids, great tensile strength, flexibility and high corrosion resistance, have ensured their successful and extensive use as biomaterials. Success of stents depends mainly on avoiding the aggregation of platelets in the blood vessels. Research in the field of nanomaterials has revealed that the topography is a crucial factor for appropriate biological response and the need to produce such surfaces for desired biological response could be the solution.

A group of scientist from Slovenian research institute, specialized in surface engineering, has developed a method that enables appropriate surface conditioning, which highly reduces adhesion and activation of platelets on the stents. In detail the method involves:

1.) nanostructuring the surface of titanium by electrochemical anodization and
2.) subjecting the nanostructured surface to neutral oxygen atoms to eliminate surface induced thrombotic reactions.

The titanium nanostructured surfaces produced by the developed method of invention have appropriate chemical structure and topography which reduces the risk of thrombosis on blood contacting devices.

The method has been tested in laboratory using blood samples, where platelet adhesion was studied on plain titanium and on surface modified by newly developed method. According to microscopic analysis on samples done by the newly developed method the platelet adhesion is prevented, as practically no platelets were observed on the surfaces prepared by this method.

Slovenian research institute is looking for producers of devices for vascular surgery such as vascular stents, heart valves and similar medical devices. The technology is ready to be licenced to a company, which would use the technology to improve the properties of the vascular stents and other medical devices. Slovenian research institute is looking also for technical cooperation agreement with companies that wish to further develop the technology in cooperation with the institute. In the later case, the company would set additional requirements for the coating technology, which would be adjusted and tested.
Advantages and Innovations:
· The developed method highly reduces adhesion and activation of platelets on the stents

· Surface treatment of vascular stents prevents formation of a thrombus and thus decreases risk of cardiovascular disease and heart attack

· The method is applicable on bare metal stents (BMS) which are three to four times less expensive than drug-eluting stents (DES)
Stage of Development:
Available for demonstration
IPs:
Patent(s) applied for but not yet granted

Partner sought

Type and Role of Partner Sought:
Type of partner:
Sought are producers of devices for vascular surgery such as vascular stents, heart valves and similar medical devices.

Role of partner:
In the case of license agreement implementation of technology to existing or emerging devices.
Cooperation in the industrial sized scale-up of the process and joint development during the pilot phase in the case of technical cooperation agreement.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English

Keywords

Technology Keywords:
06001011 Enfermedades circulatorias y del corazón
02007010 Metals and Alloys
06004 Micro y nanotecnología relacionada con las ciencias biológicas
06001013 Tecnología médica / ingeniería biomédica