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Método patentado de criopreservación de pulpa dental

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOIT20190307001
Publicado:
11/03/2019
Caducidad:
11/03/2020
Resumen:
Un centro público de investigación médica procedente de Italia especializado en asistencia sanitaria y medicina traslacional ha obtenido la patente de un método innovador, sencillo y económico para criopreservación de pulpa dental que aísla las células madre después de la criopreservación. Este método, que se utiliza en el campo de medicina regenerativa o regeneración ósea, criopreserva directamente el diente con las células madre de la pulpa dental. El método garantiza unos excelentes resultados en cuanto a los porcentajes de recuperación después de la descongelación y a la vitalidad de las células, con especial atención en su capacidad proliferativa y diferenciadora. El centro de investigación busca socios industriales interesados en establecer acuerdos de licencia o cooperación técnica.

Details

Tittle:
Patented method for dental pulp cryopreservation
Summary:
A leading Italian public medical research centre committed to healthcare and translational medicine has patented an innovative, simpler and cheaper method for cryopreserving dental pulp in order to isolate stem cells after cryopreservation. The innovative method is cryopreserving directly the tooth with its dental pulp stem cells. The medical research centre is looking for industrial partners interested in licensing agreement or technical cooperation agreement of the new method.
Description:
Adult stem cells are an inexhaustible source of multipotent cells, which can differentiate into various cell lines. Thanks to these properties, adult stem cells can be used in regenerative medicine for various purposes. Dental pulp stem cells (DPSC) can give rise to different cells of mesenchymal origin, such as osteoblasts, adipocytes, chondrocytes and muscle cells. At present, DPSC applications are mainly focused on bone regeneration in dental/maxilla-facial and orthopedic surgery. Current methods for preserving and banking dental pulp stem cells include steps in which DPSC are recovered from tooth, amplified and then stored in liquid nitrogen for further application.
The Italian medical research centre has developed a simpler and inexpensive method for cryopreserving a tooth with its dental pulp stem cells. Tooth laser perforation allow to access the root canal without overheating the dental pulp; this step contributes to ensure the integrity of the cryopreserved dental tissue, absence of bacterial contamination and high percentage of stem cells recovery. The cryopreserved dental pulp stem cells are thawed and expanded only when needed. The method ensures excellent results in terms of post-thawing recovery percentages and cells vitality scores, with particular consideration to their proliferative and differentiative capacity.
The method is useful for banking teeth and mesenchymal cells from their dental pulp. The method can be used in the field of regenerative medicine on bone regeneration.
The Italian medical research centre is looking for industrial partners interested into licensing agreement of the technology or in technical agreement for the co-development and application of the innovative method.

Advantages and Innovations:
Current methods for banking dental pulp stem cells include steps in which dental pulp stem cells are recovered from the tooth, amplified and then cryopreserved.
The innovative method is cryopreserving directly the tooth with its dental pulp stem cells. It ensures good results in terms of post-thawing recovery percentages and of vitality and proliferative capacity of the cells.
The developed method provides a lower risk of bacterial contamination of the dental pulp and of the stem cells. It ensures integrity of the cryopreserved dental tissue and high recovery percentage of stem cells.
Stage of Development:
Available for demonstration
IPs:
Patents granted
CommeR Statunts Regarding IPR Status:
Patent granted in: Europe, USA, Israel.

Partner sought

Type and Role of Partner Sought:
- Healthcare industrial partner focused in biobanking and regenerative medicine sectors interested in licensing the technology for further commercialization in relevant market..

- Industrial partner or R-Y-D institution for further co-development and new applications of the innovative method.


Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
French
Italian

Keywords

Technology Keywords:
06001004 Cirugía dental / odontología, estomatología
06003002 Expresión genética, investigación proteómica
06001009 Terapia genética - ADN