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Método y dispositivo para medir y monitorizar la concentración de sustancias en fluidos biológicos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOEE20160714002
Publicado:
13/12/2016
Caducidad:
13/12/2017
Resumen:
Un grupo de investigación estonio especializado en ingeniería biomédica ofrece un método óptico y dispositivo para medir y monitorizar cuantitativamente concentraciones de sustancias en fluidos biológicos y calcular la dosis de diálisis de solutos de retención urémica difusibles. Este dispositivo está indicado para la revisión automática de la calidad de la dosis de diálisis administrada y del estado nutricional de pacientes con enfermedad renal. El grupo de investigación busca socios con el fin de establecer acuerdos de comercialización con asistencia técnica, licencia e investigación.

Details

Tittle:
Method and device for measuring and monitoring concentration of substances in a biological fluid
Summary:
Estonian research group from biomedical engineering offers an optical method and device for measuring and monitoring quantitatively concentrations of substances in biological fluid, and calculation of the dialysis dose for diffusible uremic retention solutes. It is suitable for automatic way to review the delivered dialysis quality and nutritional status of the renal disease patients. They are looking for commercial agreement with technical assistance, license and research cooperation agreement.
Description:
The uremic syndrome is attributed to the progressive retention of a large number of compounds (uremic retention solutes), which under normal conditions are excreted by healthy kidneys. Monitoring of the important biological constituents in biological fluids from the medical point of view can prevent serious pathological conditions and decrease mortality of patients.

Currently these compounds are estimated in lab using blood tests and bio-analyzers. However 1) some compounds in the sample of biological fluid are similar to each other that may effect test accuracy; 2) the operations are complex requiring a range of agents, and professional staff; 3) the sample must be pre-treated; 4) the necessary equipment is expensive; and 5) the results appear with a delay.

Thus, there is a need for a new method which can directly and easily monitor removal of different uremic retention solutes during hemodialysis and perform quantitative concentration measurements of water soluble middle and small molecular weight and protein bound uremic toxins in the biological fluids. The merits of the described method are that it does not need blood samples, no disposables or chemicals, and is fast. Moreover, it is suitable for estimation of nutritional status (protein nitrogen appearance and lean body mass) on dialysis patients and avoids the disadvantages caused by the analysis in a laboratory.

The present invention relates to an optical method utilizing the unique set of optical spectral components at certain wavelengths of an optical spectrum of the biological fluids and UV- absorbance, preferable UV-absorbance of the spent dialysate or the peritoneal liquid, and concentration calculation algorithm containing the transforming function to determine on the samples or on-line the concentration of the substances, which can be effected directly at the bed-side, real-time and which avoids the disadvantages caused by the analysis in a laboratory.

The method and device determines the concentration of the substances in-vitro or on-line utilizing a measuring cuvette (cell) suitable for specified measurements. The light source and the light detector are operating in wavelength range 180-400 nm. The purpose of the invention is, therefore, a new method and a device for measuring concentration of substances (e.g. middle molecular weight solutes - (MM) (MW > 500 g/mol): -Y-beta;2-microglobulin, Cytokines (Interleukin 6), Parathyroid hormon (PTH) - at the same time belongs to the protein-bound group, small molecular weight solutes - (MW < 500 g/mol): Urea, Creatinine, Uric acid, Guanidine -ADMA (asymmetric dimethylarginine), Phosphate) in biological fluids and monitoring removal of the said hardly and easily diffusible uremic retention solutes during dialysis.

Additionally, a new, simplified mapping of dialysis dose and nutrition is proposed by using only two parameters - Kt/V and nPNA, suitable for automatic and time-efficient way to review the performed HD strategy based on the data from on-line dialysate side dialysis monitors. The novel method for quantitative concentration measurements of uremic retention solutes in the biological fluids combined with the new, simplified mapping of dialysis dose and nutrition, gives an added value for the real-time, automatic monitoring of dialysis patients.

Moreover, a parameter Lean Body Mass, suitable for automatic and time-efficient way to review the muscle mass and protein nutritional status of the HD patients, can be monitored by the novel method for quantitative concentration measurements of uremic retention solutes in the biological fluids.

We are looking for commercial agreements with technical assistance, and license agreements with companies who
provide technology solutions for biomedicine /biomedical technologies; and research cooperation with R-Y-D centres of medicine technology companies and universities to jointly develop analysis methods, point of care devices, and dialysis quality assessments.
Advantages and Innovations:
Main advantages and innovations compared to competitors are that the novel method and device does not require any chemical disposables, neither expensive separation techniques and can be easily made and mass-produced providing an environment-friendly optical method. The technology is suitable for automatic and time-efficient way to review the dialysis quality delivered to the end stage renal disease patients. The method and device determines the concentration of the substances in-vitro or on-line. The technology is potentially usable in home conditions. In sum, the invention offers simple, rapid, compact, inexpensive, mobile and reliable method that does not need blood samples, any disposables or chemicals. The method utilizes certain spectral components of UV- spectrum.
Stage of Development:
Prototype available for demonstration
IPs:
Patents granted

Partner sought

Type and Role of Partner Sought:
The research group is looking for: commercial agreement with technical assistance and license agreements with companies who
would provide technology solutions for biomedicine /biomedical technologies; Research cooperation agreements with bigger medicine technology companies who have R-Y-D centres and universities in the same area to jointly develop analysis methods, point of care devices, dialysis quality assessments.

These cooperation types were chosen because they are most suitable and possible for the commercialization and further development of this technology.

Under commercial agreements with technological assistance, it is expected that the partner develops the commercialized solution in collaboration with and technical support from the research group according to the set contract.

Under licencing agreement, it is expected that the partner will receive the license and use it according to the contract.

Under R-Y-D cooperation, experiments with new substances and more accurate algorithms could be developed. Methods for other bio-fluids or using the same method on other substances to analyse concentrations in other bio-fluids could also be developed. In addition, R-Y-D according to clients/partner interests can also be envisaged.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Estonian
Finnish
German
Russian
Swedish

Keywords

Technology Keywords:
06002007 Ensayos in vitro, experimentos
06001002 Investigaciones clínicas, ensayos
06001012 Investigaciones médicas
06005002 Sensores y productos inalámbricos
06001013 Tecnología médica / ingeniería biomédica