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Microorganismos fermentativos para la biotransformación de azúcares celulósicos en biocombustibles y bioquímicos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20190228001
Publicado:
28/02/2019
Caducidad:
29/02/2020
Resumen:
Un instituto de investigación español que trabaja en el campo de energías sostenibles está desarrollando nuevas cepas de levadura comerciales para convertir hidrolizados lignocelulósicos en etanol y otros productos de alto valor. El instituto está trabajando en el desarrollo de microorganismos adaptados que puedan transformar hidrolizados lignocelulósicos en presencia de inhibidores de forma eficiente. Los microorganismos pueden emplearse en entornos hostiles, obteniendo un proceso de biotransformación necesario para incrementar su rendimiento. El instituto busca empresas que trabajen en el sector de biocombustibles y bioproductos obtenidos a partir de azúcares lignocelulósicos con el fin de establecer acuerdos de cooperación técnica o en materia de investigación.

Details

Tittle:
Fermentative microorganisms for the biotransformation of cellulosic sugars into biofuels and biochemicals
Summary:
A Spanish R-Y-D institute, working on sustainable energies, is developing new commercial yeast strains for converting lignocellulose hydrolyzates into ethanol or other high-value products.

Companies working on biofuels and/or bioproducts from lignocellulosic sugars are sought for technical cooperation and/or research cooperation agreements.
Description:
Under ideal conditions, fermenting microorganisms are capable to consume sugars and produce ethanol and other high-value products. However, the conditions in the biotransformation process of lignocellulosic sugars are anything but ideal. The lignocellulose hydrolysates generated after pretreatment and hydrolysis contains not only fermentable sugars but also several compounds (such as acetic acid, furans, and phenols) that are toxic for the microorganisms. This constitutes the hydrolysates as an exceptionally difficult substrate for biotechnological conversion to biofuels or biochemicals.
Furthermore, high-solids concentration during the biotransformation process is needed to increase the profitability of the process. These high-loadings exert stress on the cell affecting its tolerance to inhibitors. Since an intermediate purification step of the hydrolysate is usually not a viable process option, a key requirement for efficient biotransformation of cellulosic sugars is a microbial strain that combines good fermentation capabilities with high robustness to the
complex conditions of the hydrolysate. Thereof current microorganisms used in the ethanol industry do not function well in this hostile environment.
The institute, located in Spain and focused on sustainable energy sources including biofuels, is working on developing adapted microorganisms that can efficiently convert lignocellulosic hydrolysates in presence of inhibitors.
They are searching for the key metabolic, physiologic, genetic, and regulatory mechanisms underlying stress tolerance and adaptation.
Now, they are looking for companies with expertise and facilities to produce biofuels and/or bioproducts from lignocellulosic sugars. Its main role will be to check the performance of fermenting microorganisms under technical cooperation or research cooperation agreement.

Advantages and Innovations:
Development of new commercial yeast strains via directed evolution, genetic engineering, and/or adaptation for converting lignocellulose hydrolyzates into ethanol or other high value
products.
Obtaining microorganisms with robustness able to be used in hostile environment, obtaining a biotransformation process needed to increase the profitability of the process.
Stage of Development:
Under development/lab tested
IPs:
Secret Know-how

Partner sought

Type and Role of Partner Sought:
Company with expertise and facilities to produce biofuels and/or bioproducts from lignocellulosic sugars. Its main role would be to check the performance of fermenting microorganisms under
technical cooperation or research cooperation agreement.

As they are open to further development and collaboration, further roles and collaborations will be defined with the company.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
04005003 Biocombustibles líquidos
06002002 Biología celular y molecular
04005011 Biorefinerías para energía
06006011 Fermentación
06002008 Microbiología