Con esta herramienta te facilitamos un acceso a todas las ofertas y demandas de tecnología europeas y a búsquedas de socios para participar en propuestas europeas de I+D publicadas en la red Enterprise Europe Network, pudiendo filtrar los resultados para facilitar las búsquedas más acordes con tus necesidades.

¿Quieres recibir estos listados de oportunidades de colaboración en tu correo de forma periódica y personalizada? Date de alta en nuestro Boletín

Los términos de búsqueda han de ser en inglés.

Mimetic lymph nodes for immune cells culture

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20200831001
Publicado:
21/09/2020
Caducidad:
22/09/2021
Resumen:
A Spanish research institution has developed a new 3D scaffold that mimics the lymph nodes for the proliferation and differentiation of immune cells, such as T lymphocytes, ready for immunotherapy applications. Industrial partners are being sought to collaborate through patent license and research cooperation.

Details

Tittle:
Mimetic lymph nodes for immune cells culture
Summary:
A Spanish research institution has developed a new 3D scaffold that mimics the lymph nodes for the proliferation and differentiation of immune cells, such as T lymphocytes, ready for immunotherapy applications.

Industrial partners are being sought to collaborate through patent license and research cooperation
Description:
A Spanish research institution has developed a new hydrogel for 3D culture.

Immunotherapy offers a different approach than standard surgery, radiation and chemoterapy procedures against cancer. It is based on employing and reinforcing the immune system of patients, surpassing cancer immunosuppression methods, detecting and eliminating malignant cells without damaging healthy tissues.

Adoptive cell therapy, a type of personalized immunotherapy that has achieved complete remissions of advanced cancer patients, requires large expansions of immune cells, in order to have relevant quantities of therapeutic cells to be used as "alive drugs". The implementation of these therapies to the clinics is limited by the current cell expansion methods.

The new mimetic lymph nodes, which are based on a 3D scaffold made of loadable PEG heparin hydrogel, with immune-relevant molecules, provide higher cell proliferation rates and capacity to tune the obtained phenotypes than the gold standard.

The Spanish research institution is searching for a company interested in the development and commercialization of this hydrogel for 3D culture under a license agreement, and its also open to establish a research cooperation agreement with the company to, further develop the hydrogel and optimize the production, according to the company interests.
Advantages and Innovations:
- Higher cell proliferation rates

-Tunable phenotype proportions

-Different combinations of immune molecules available to customize cell differentiation
Stage of Development:
Field tested/evaluated
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
European patent application

Partner sought

Type and Role of Partner Sought:
Industrial partner in the health sector interested in the development, commercialization of the 3D cell culture hydrogel under a license agreement are sought.

-Licensing agreement: the partner would license the technology to carry out commercialization of the 3D cell culture hydrogel.

Research cooperation agreement: The partner and the Spanish research institution could undertake a joint effort to further develop and optimize the product, addressing to specific needs of the market.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06001003 Citología, cancerología, oncología
06004 Micro y nanotecnología relacionada con las ciencias biológicas