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Modificación química avanzada de superficies para micro y nanodispositivos y aplicaciones de biología


Oferta Tecnológica
Una spin-off de una universidad holandesa ha desarrollado nuevos métodos de modificación química de superficies que permiten la deposición local y selectiva en materiales de revestimientos moleculares de espesor nanométrico. Estos métodos permiten adaptar las propiedades superficiales de diversos materiales inorgánicos, mejorando el rendimiento de biosensores, dispositivos lab-on-a-chip y otros micro y nanodispositivos. La empresa ofrece nanorrevestimientos a medida y está interesada en establecer acuerdos de licencia, fabricación, servicio o cooperación técnica.


Advanced chemical surface modification for micro- and nanodevices and life sciences applications
A Dutch university spin-off has developed novel methods for chemical surface modification, enabling local and material-selective deposition of nanometre thick molecular coatings. The surface properties of various inorganic materials can be adjusted, improving the performance of biosensors, labs-on-a-chip and other micro- and nanodevices. The company offers tailor-made nano coating solutions in a licence, manufacturing, services or technical cooperation agreement.
A Dutch university spin-off offers the development and application of customized surface modification solutions. The company has extensive experience with a wide range of surface modification chemistries. Moreover, it has developed its own proprietary methods for local and material-selective surface modification, based on over a decade of research in this field.
Accurate control of surface properties is an essential requirement for the optimum performance of micro- and nanodevices. For example, a bioreceptor needs to be immobilized on the surface of a biosensor, and the walls of microfluidic channels need to be hydrophilic to facilitate capillary flow. These properties can be achieved by chemical surface modification, i.e. covalently attaching molecules with the desired properties to the device.

A wide variety of materials can be coated, examples include:
- silicon-containing materials (oxide-free silicon, silicon oxide, nitride, carbide, ...)
- oxide materials (glass, aluminium oxide, titanium oxide, indium tin oxide (ITO), ...).
- metals (gold, platinum, ...)

These materials can be endowed with various surface properties, including:
- hydrophobic / hydrophilic
- biofunctionalization, biorecognition
- biocompatibility
- anti(bio)fouling, protein- or cell-repellent

Examples of micro- and nanostructures and devices which can be (and have been) coated include:
- biosensors
- nanowires
- microsieves
- AFM cantilevers
- microneedles
- microfluidics

The company is interested in meeting new partners in the field of university, research or manufacturing to further develop new customized applications based on technical cooperation agreement resulting in a long term licence agreement, production agreement or services agreement.
Advantages and Innovations:
Most state-of-the-art methods for chemical surface modification are based on self-assembly. Examples are monolayers of thiols on noble metals and of silanes and phosphonates on oxides. These methods lead to uniform coatings, and patterns can be created only by multistep procedures such as photolithography or micro contact printing. In contrast, the proprietary methods developed by the company are based on ´triggered assembly´, and allow local and material-selective surface modification in a single step. Further modification of the primary coating and backfilling of uncoated areas are possible as well.

Many micro-and nanodevices and technologies can benefit from local control of surface properties, i.e. patterns of different functionalities. For example, the performance of biosensors can be improved by selectively attaching the bioreceptor to the sensing area, while applying an inert coating (to which the analyte does not bind) to the rest of the device. Thus, the analyte is concentrated on the sensing area, improving the sensitivity of the sensor.

Beside the biosensor example mentioned above, there are many other applications which can benefit from patterned coatings, i.e. local or material-selective surface modification. These include microfluidic systems (lab-on-a-chip, organ-on-a-chip, miniaturized diagnostic devices), substrates for microarrays, 3D cell culture, single cell studies and other biochips.
Stage of Development:
Already on the market
Secret Know-how,Patents granted
CommeR Statunts Regarding IPR Status:
Patents granted in various countries depending on the application and technology used. Further information provided on request.

Partner sought

Type and Role of Partner Sought:
The company is looking for long term business partners active in research, development and laboratory of fluids that are in need of new technology for their measuring devices using custom developed surface modification technology.
Companies active in the production of "lab on a chip" devices that are in need of new testing devices are welcome to discuss licence agreement possibilities or technical cooperation agreement.


Type and Size of Client:
Industry SME 11-49
Already Engaged in Trans-National Cooperation:
Languages Spoken:


Technology Keywords:
01002002 Impresión 3D
01002001 Micro and Nanotechnology related to Electronics and Microelectronics
02002002 Recubrimientos
03004010 Special chemicals, intermediates