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Nanoobjetos híbridos para imágenes médicas y administración de fármacos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOFR20171114001
Publicado:
11/01/2018
Caducidad:
11/01/2019
Resumen:
Un laboratorio de una universidad francesa especializado en química y biotecnología ha obtenido la patente de un método para producir nanoobjetos con propiedades y funciones específicas. Estos nanoobjetos con núcleo acuoso están envueltos en un revestimiento híbrido hecho de nanopartículas poliméricas orgánicas o nanopartículas magnéticas inorgánicas. El núcleo puede encapsular un agente fluorescente o principio activo farmacéutico para terapia. El revestimiento de nanopartículas ferromagnéticas es útil como agente de contraste para imagen de resonancia magnética. El laboratorio busca empresas con el fin de establecer acuerdos de licencia.

Details

Tittle:
Hybrid nano-objects for medical imagery and drug delivery
Summary:
A French university laboratory specialised in chemistry and biotechnology has patented a method to produce nano-objects with specific properties and dedicated functions. They are in the shape of aqueous core wrapped in hybrid shell. The core can encapsulate a fluorescing agent or an active pharmaceutical ingredient for therapy. The ferromagnetic nanoparticle shell is useful as a contrast agent for magnetic resonance imagery. The laboratory is seeking industrial companies for license agreements.
Description:
A French university laboratory discovered and patented a method to produce new nano-objects for use in medical imaging and also as vectoring agents. The invention also relates to the process for preparing these nano-objects with specific properties and dedicated functions. These nano-objects consist in an aqueous cores covered by a hybrid shell made of organic polymer and inorganic magnetic nanoparticles (see picture).

The aqueous core is able to encapsulate an active pharmaceutical ingredient or a fluorescent imaging agent. The ferromagnetic nanoparticle shell is useful as a contrast agent for magnetic resonance imagery.

The shells are made of inorganic nanoparticles (iron oxides, gold, quantum dots or a mixture of nanoparticles). Polymers can be of various type such as poly(acrylic acid), PVP, poly(glycol ethylene). Nanoparticles and polymers create an hybrid shell of 70 to 150 nm able to encapsulate a fluorescing agent, a therapeutic small molecule or a radioelement. Polymers can be grafted with peptides, antibodies, aphtamers to target specific cells and organs. Grafting of the polymer with vectorization compounds such as antibodies is possible in order to target specific cells and organs (cancer cells for instance).

The nano-objects can act in all types of medical imaging and also as vectoring agents. The French laboratory is seeking industrial companies for license agreements or research cooperation agreements.
Advantages and Innovations:
Used in imagery medicine and to combine with therapy / drug delivery.

Decreased toxicity and increased efficacy of imaging agents and therapeutic treatments.

Simple and economical production process thanks to a method of self-assembly of inorganic nanoparticles and polymers.
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted,Trade Marks
CommeR Statunts Regarding IPR Status:
National patent

Partner sought

Type and Role of Partner Sought:
The French Laboratory is mainly looking for partners such as SME or start-up in the fields of drug delivery, therapy, imagery, oncology, nanomedicine in order to create a R-Y-D partnership that will be financially supported by the French university and with the aim to lead to a licence agreement in the future. The French Laboratory is open to further research cooperation with companies in the medical sector or others.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English
French

Keywords

Technology Keywords:
06001003 Citología, cancerología, oncología
06001005 Diagnósticos, diagnosis
02007023 Materiales híbridos
02007024 Nanomaterials
03004007 Pharmaceutics