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Nanovesículas fluorescentes para aplicaciones de imagen y biodetección en pruebas de diagnóstico

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20180525001
Publicado:
27/06/2018
Caducidad:
23/06/2019
Resumen:
Un centro de investigación catalán ha desarrollado y obtenido la patente de una nanoestructura fluorescente (<100nm) con una estabilidad superior y excelentes propiedades ópticas para aplicaciones de bioimagen. Las nanovesículas fluorescentes se producen mediante un proceso ecológico y pueden interactuar con la región hidrofóbica o hidrofílica de la bicapa, permitiendo una aplicación selectiva. Estas nanovesículas patentadas han sido probadas como sondas eficientes en imágenes in vivo e in vitro y pueden utilizarse en aplicaciones de imagen, teranósticas y médicas. El centro de investigación busca socios industriales que desarrollen herramientas de diagnóstico o agentes de contraste interesados en utilizar la tecnología y establecer acuerdos de licencia.

Details

Tittle:
fluorescent nanovesicles for imaging and biosensing applications in diagnostic tests
Summary:
A Catalan research center patented a fluorescent nanostructure (<100nm) with superior stability and remarkable optical properties for bioimaging applications. The fluorescent nanovesicles are produced by a green process and can interact with the hydrophobic or hydrophilic region of the bilayer allowing a targeted application. They are looking for Industrial partners developing diagnostic tools or contrast agents interested in the technology and willing to use it through a license agreement.
Description:
A Catalan Research Center patented a new fluorescent nanostructure with superior stability and remarkable optical properties based on a nanovesicle bearing fluorescent organic dyes, irrespective of their physico-chemical and optical properties.

Fluorescent organic dyes are widely investigated as fluorescent probes in microscopy, thanks to their tunable optical and physicochemical properties via chemical modification of their structure.Good fluorescent probes for microscopy should be
bright and highly photostable; water soluble; and chemically stable in buffers, cell media, or body fluids; as well as capable of site-specific labeling and showing biocompatibility.

Delivery of hydrophobic materials in biological systems, for example contrast agents or drugs, is an obdurate challenge, severely restricting the use of materials with otherwise advantageous properties.

Loading an organic dye into a nonfluorescent nanocarrier, arranged as fluorescent organic nanoparticle offers an interesting strategy to bring organic dyes in aqueous media, since the obtained nanovesilces have good brightness, photostability, and biocompatibility


These fluorescent nanovesicles patented by the Catlan Research Center have been proved as efficient probes for in vivo and in vitro imaging and have potential applications in imaging, theranostic and medical applications.


The fluorescent nanovesicles can interact with the hydrophobic or the hydrophilic region of the bilayer.

The preparation of the fluorescent nanovesicles offers a great potential for the development of multifunctional nanovesicles integrating for example drugs, peptides and imaging agents.

Moreover, the fluorescent nanovesicles can incorporate simultaneously several dyes, obtaining probes for more complex applications, such as multicolor imaging. This platform is especially effective for the conveyance of non-water-soluble dyes whose optical properties are usually not stable in physiological media, but remain efficient after incorporation in nanovesicles.


The obtained nanovesicles, prepared by a CO2-based technology,show excellent colloidal- and photostability, outperforming other nanoformulations of the dyes, and improve the optical properties of the fluorophores in water.

Therefore, these fluorescent nanovesicles constitute an appealing nanomaterial for bioimaging applications.
The partner sought would be an Industrial company developing diagnostic tools and contrast agents interested to collaborate through a licence agreement to use this technology and bring the product to the market.
Advantages and Innovations:
Fluorescent nanovesicles, with sizes of less than 100 nm, are prepared by a green, single-step, robust and easily scalable CO2-based methodology leading the formation of multifunctional
nanovesicles with superior structural homogeneity

This process guarantees superior structural homogeneity, both
regarding size and lamellarity, and reproducibility.

The fluorescent nanovesicles are chemically, physically and optically stable during several months.
Stage of Development:
Available for demonstration
IPs:
Patent(s) applied for but not yet granted

Partner sought

Type and Role of Partner Sought:
Industrial partners developing diagnostic tools, contrast agents, fluorescent probes for sensing or imaging, or theranostic formulations, are being sought to collaborate through a license agreement.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English

Keywords

Technology Keywords:
06004 Micro y nanotecnología relacionada con las ciencias biológicas
06006006 Nanomateriales biológicos
02007024 Nanomaterials
06001015 Productos farmacéuticos / medicamentos