Con esta herramienta te facilitamos un acceso a todas las ofertas y demandas de tecnología europeas y a búsquedas de socios para participar en propuestas europeas de I+D publicadas en la red Enterprise Europe Network, pudiendo filtrar los resultados para facilitar las búsquedas más acordes con tus necesidades.

¿Quieres recibir estos listados de oportunidades de colaboración en tu correo de forma periódica y personalizada? Date de alta en nuestro Boletín

Para optimizar los resultados de la búsqueda, se recomienda utilizar términos en inglés.

New therapeutic approach in a multiplicity of neurodegenerative and autoinflammatory pathologies

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOIT20201022001
Publicado:
04/11/2020
Caducidad:
05/11/2021
Resumen:
An Italian research group has developed new therapeutic approaches to neurodegenerative and autoinflammatory pathologies. The research group is interested in finding partners for developing the research targeting neurological diseases. Partners may be pharmaceutical companies, startup or other research groups interested in research collaborations, in technical or research cooperation agreements or joint future developments of a product.

Details

Tittle:
New therapeutic approach in a multiplicity of neurodegenerative and autoinflammatory pathologies
Summary:
An Italian research group has developed new therapeutic approaches to neurodegenerative and autoinflammatory pathologies. The research group is interested in finding partners for developing the research targeting neurological diseases. Partners may be pharmaceutical companies, startup or other research groups interested in research collaborations, in technical or research cooperation agreements or joint future developments of a product.
Description:
Recent findings have highlighted the important role played by the disregulated activation of the innate immune system in the onset and progression of several neurological and autoinflammatory diseases.
Small organic molecules able to modulate the activation of the immune system have, therefore, a great potential in the identification of a therapeutic approach for a multiplicity of neurodegenerative and autoinflammatory pathologies. The inhibition of the caspase-1 enzyme may allow to modulate the release of proinflammatory cytokines deriving from the activation of the inflammasome, blocking the inflammatory process. To date, there are no caspase-1 inhibitors that can be used in the clinic. In fact, although numerous caspase-1 inhibitors have been synthesized, no inhibitor has passed the clinical trial, probably because of the covalent mechanism of action and the consequent unwanted off-target interactions.
The Italian research group, in collaboration with a foreign University, is interested in finding possible partners with whom to further develop the technology through technical or research cooperation agreements or joint developments.
Advantages and Innovations:
The research result and patent related, claims a new class of molecules able to inhibit caspase-1 to modulate innate immune system and in inflammatory processes. The new molecules discovered present innovative characteristics, with respect to the molecules currently known, because of their non-covalent mechanism of action.
Stage of Development:
Under development/lab tested
IPs:
Patents granted

Partner sought

Type and Role of Partner Sought:
Italian research group is interested in pharmaceutical companies or other research organisations for further developing the product, through research and development or technical collaboration agreements.

Client

Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Italian

Keywords

Technology Keywords:
06002002 Biología celular y molecular
06002009 Diseño molecular
06002007 Ensayos in vitro, experimentos
06001014 Neurología, investigación cerebral
06001015 Productos farmacéuticos / medicamentos