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Nueva solución basada en nanopartículas poliméricas para mejorar las terapias contra el cáncer

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20160531004
Publicado:
20/06/2016
Caducidad:
20/06/2017
Resumen:
Un equipo de investigación español especializado en oncología ha desarrollado una solución innovadora para mejorar el tratamiento contra el cáncer. Se trata de un sistema de vehiculización de biomoléculas activas mediante nanopartículas que dirige las biomoléculas hacia las zonas objetivo de forma efectiva y selectiva. El equipo de investigación busca colaboración para transferir la tecnología mediante un acuerdo de licencia o para continuar con el desarrollo de la solución y establecer un acuerdo de cooperación técnica.

Details

Tittle:
New solution based on polymeric nanoparticles for the improvement of anticancer therapies, developed by a Spanish research group
Summary:
A Spanish research group, specialized in medical oncology, has developed an innovative solution for the improvement of anticancer treatments, related to a system for the vehiculization of active bio-molecules through nanoparticules, able to lead them towards the target zones in an effective and selective manner.

The group is seeking collaboration to transfer the technology through a license agreement or to further develop the solution, through a technical cooperation agreement.
Description:
A Spanish research group from the Andalusian public health system, whose field of activity is the medical oncology, supported by two Universities, has developed a new solution based on nanoparticles sustained release of active ingredients, this will enable to improve the efficiency and results of some antitumor therapies.

The need to find an effective treatment against cancer has caused the diversification of the research lines on this field, leading to identify new therapeutic strategies and to develop a wide range of new active agents. But some of those new generated molecules have limitations related to: the impossibility for enough quantity to reach the area of the tumor, the unfavorable pharmacokinetics of anti-tumor agents wich forces to use highly toxic doses, and the difficulties to focus the treatments in the affected area in order to avoid treatment adverse effects.

In order to address this problem, the research group has investigated the applications of bio- and nanotechnology; finally as result of its work, the group got the innovative solution exposed in this profile.

This new system for transporting biologically active molecules, is capable of being targeted to receptors or targets selectively, and in particular to the functionalization of nanoparticles of poly (butyl cyanoacrylate) (PBCA) or poly (¿-caprolactone) (PCL) that transporting a drug, preferably 5-fluorouracil.

These new nanoparticles behave as an excellent carrier system pyrimidine analogs, specifically to 5-fluorouracil. They allow an optimum vehiculization of the anticancer agent, reaching a high extravasation into the tumor mass and, in turn, the drug releasing is more controlled. In addition, antitumor efficacy in vitro studies have demonstrated a significant increase of drug´s antitumor activity when it is carried by the new nanoparticles.

The research group aims to formalize a technology transfer process with entities interested in the implementation of the solution, through a license agreement. If there are some entities, such as R-Y-D centers, technology centers or specialized companies, interested in collaborate and develop further aspects of the solution, a technical cooperation agreement could be envisaged.
Advantages and Innovations:
The conclusions of the implemented in vitro and in vivo tests, show some of the solution advantages:

(using poly (butylcyanoacrylate) (PBCA) and poly (¿-caprolactone) (PCL) for the transportation of 5-fluorouracil)

1. It increases the antiproliferative activity of the drug up to 61.9%

2. It reduces by up to 50.8% the tumor volume of colon cancer developed in mice, compared to the drug activity without nanoparticles.

3. It significantly increases the survival time of mice with tumors, compared to the treatment with the drug without nanoparticles.

4. The developed nanoparticles do not show any toxicity
Stage of Development:
Under development/lab tested
IPs:
Patents granted
CommeR Statunts Regarding IPR Status:
International patent PCT

Partner sought

Type and Role of Partner Sought:
Type of partner sought:
SMEs, companies and R-Y-D Institution with expertise in cancer treatment and anticancer drugs development

Field of activity:
Oncology, pharmacology

Task to be performed by the partner:
-Arrangement of the condition of the license agreement and co-working for the implementation of the solution

-Co-development of further aspects of the solution and its improvement

Client

Type and Size of Client:
Other
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06001003 Citología, cancerología, oncología
06001002 Investigaciones clínicas, ensayos
06001015 Productos farmacéuticos / medicamentos