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Nueva tecnología de preparación de dendrímeros para el tratamiento de trastornos genéticos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20150804001
Publicado:
05/08/2015
Caducidad:
04/08/2016
Resumen:
Un grupo de investigación español ha desarrollado una nueva tecnología de preparación de dendrímeros funcionalizados con grupos alquil-sulfonilo. Estos compuestos actúan como vectores de administración de genes virales y tienen mejores propiedades de transfección. El grupo de investigación busca compañías de los sectores de biotecnología y salud que trabajen en terapia de genes para el tratamiento de trastornos genéticos con el fin de establecer acuerdos de licencia.

Details

Tittle:
New technology for the preparation of dendrimers for treating genetic disorders.
Summary:
A Spanish research group has developed a new technology for the preparation of dendrimers functionalized with alkyl sulfonyl groups. These compounds act as non viral gene delivery vectors and have improved transfection properties. The research group is looking for a licence agreement with companies in the biotechnology and health sector.
Description:
The potential of gene therapy for treating genetic disorders has led to a prolific research activity on the design of safe and efficient gene carrier vectors that compact and protect DNA against degradation.

Nonviral vector systems are an attractive alternative to viral carriers, retroviruses and adenoviruses, to overcome fundamental problems associated with these systems despite the high delivering efficiency that they exhibit: toxicity, immunogenicity and limitations related with scale-up production.

The present technology allows the preparation of amphiphilic PAMAM- based dendrimer bearing alkyl sulfonyl hydrophobic tails in some of the amino pheripheral groups. These compounds are easily and efficiently prepared by means of the aza-Michael type addition of its primary amino groups to vinylsulfone derivatives as an efficient tool for surface engineering.

The flexibility of the vinylsulfone based chemistry also allowed the fluorescent labeling of these PAMAM derivatives for the preparation of probes to monitor the endocytic pathway used for successful transfection by the dendrimers.

The research group is looking for a licence agreement with companies in the biotechnology and health sector that work with gene therapies for treating genetic disorders.
Advantages and Innovations:
- Straightforward and efficient preparation amphiphilic dendrimers

- Chemical strategy that is general and flexible allowing the easy functionalization of any amino-containing polymer for the preparation of synthetic gene carriers.

- Preparation of engineered gene vectors with improved properties

- Easy preparation of fluorescent gene vectors that allow monitoring of the internalization of those gene carriers.
Stage of Development:
Available for demonstration
IPs:
Patent(s) applied for but not yet granted

Partner sought

Type and Role of Partner Sought:
· The type of partner sought:
A partner from the private industry is sought.

· The specific area of activity of the partner:
A company from the biotechnology, health sciences or pharmaceutical area.

· The tasks to be performed by the partner sought:
The partner should work in the field of treatment of genetic disorders and thus be interested in a licensing agreement in order to take advantage by using the new technology.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06001015 Productos farmacéuticos / medicamentos
06001009 Terapia genética - ADN