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Nuevas espumas de poliuretano autoexpandibles para relleno inerte de cavidades pleurales y otras cavidades humanas

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20170328002
Publicado:
05/04/2017
Caducidad:
05/04/2018
Resumen:
Una universidad española ha desarrollado una nueva espuma polimérica para el relleno y sellado in situ de cavidades humanas internas de diversas formas irregulares. Este material puede autoexpandirse y automoldearse para evitar complicaciones en cavidades internas abiertas causadas por infecciones, hemorragia, fístulas, disnea o sepsis. La espuma se aplica fácilmente, es segura y evita el uso de los tratamientos agresivos actuales en cavidades pleurales. La universidad busca empresas con el fin de establecer acuerdos de licencia o cooperación técnica.

Details

Tittle:
Novel self-expanding polyurethane foams intended for inert filling of pleural and other human cavities.
Summary:
A Spanish university has developed a new polymeric foaming material for in-situ filling and sealing of internal irregular different shaped human cavities. It can be self-expanded and self-moulded for avoiding complications in open internal cavities caused by infections, blooding, fistulae, dyspnoea or sepsis. It is easily applicable, safe and avoids the use of current aggressive treatments in pleural cavities. Companies are sought for licensing or technical cooperation agreements.
Description:
The pleural cavity contains a minimal amount of liquid to maintain the negative pressure needed for an adequate pulmonary function. Several pathologies of the pleural cavity produce air or biological liquids (pus, blood, pleural openings, etc.) that are commonly solved by draining. However, some pathologies cause chronification leading to severe clinical complications such as infections, sepsis, fistulae, pain, haemorrhages or dyspnoeas.

The current treatments for draining the pleural cavities are mainly decortications, toracoplasties, thoracotomies, pedicular inserts, thoracic openings, and filling with different synthetic materials, which are aggressive and may cause severe clinical complications such as infections of fistulae. Copolymers of lactic acid and caprolactone have also been used but they cannot be injected throughout small cavities because they are not self-expandable and show insufficient mechanical properties.

Currently, several polyurethane foams intended for biomedical applications have been developed following two different approaches:
1. Biocompatible polyurethane foams containing different functional compounds for imparting self-adhesion properties.
2. Mixing of thermoplastic polyurethanes and biodegradable polyesters derived from polilactic acid able to produce closed-cell foams with good contraction and biocompatibility.

A Spanish research group has developed a new polymeric foaming material for in-situ filling and sealing of internal irregular different shaped human cavities, intended for patients suffering chronic pleural cavities and in-field injuries caused by bullets or accidental event leaving open blood vessels.

The new polymeric foams show a solid and a gas phase dispersed into the polymeric matrix, forming discrete or interconnected cells. The formation of in-situ polyurethane foams is reached by mixing two liquid components that can be injected by means of a double-container syringe. The two liquids components may have different compositions:

-Component 1: it may contain water, polyols, foaming agents, catalysts, surfactants, other polymers, plasticizers, inorganic and/or organic fillers, processing aids, rheological additives, radiological tracers and antibiotics, among other.

-Component 2: it contains isocyanate or isocyanates mixture.

Both components are liquid at room temperature and they can be mixed in few seconds before injecting the mixture in a syringe or in a dosing device to its deposition in liquid state in the internal human cavity (pleural cavity, blooding vessel, injury in the field). Thus, the foaming can be controlled for being fast or slow (less than one minute in any case). The composition is designed to start the foaming during the application of the two liquid components avoiding that the liquids can be in contact with the tissues surrounding the cavity.

The component 1 can be homogenized by mechanical stirring in less than one minute. Since the component 2 is liquid, it can be easily manipulated. The two liquid components can be mixed by mechanical stirring in less than 20 seconds. By changing the ratio of the two components, the foaming process can be controlled to be adapted to the specific cavity and to different geometries, shapes and size of the cavities.

They can be formulated for rending flexible, semi-rigid or rigid foams. In all cases a homogeneous size and cell distribution is obtained and all of them show adequate mechanical resistance.

The present invention can be applied in biomedical and veterinary sectors for the filling of internal cavities. It can be also used in accidental and in-field lesions or injuries causing blood bleeding.

The research group is looking for companies interested in acquiring this invention for commercial exploitation through licensing agreement or technical cooperation (Development of new applications, adaptation to specific needs of the company, technical reports and scientific assessment, etc
Advantages and Innovations:
The new polyurethane foam is intended for filling internal human or animal cavities having different shapes and sizes. The most innovative aspect is the fact that they are self-expandable and self-modelled.

The main advantages of the novel developed foam are:
· Easy to apply, even though very small orifices.
· No adhesion to surrounding tissues.
· Very low density (i.e. low weight).
· It can be easily removed from the internal cavity, if necessary.
· Biocompatible and low risk of toxicity, carcinogenesis and local clinical complications.
· It can be dosed into open or closed cavities.
· It can be applied in the presence of blood or biological liquids.
· The resulting foams do not deteriorate over time and are stable.
· It does not cause infections.
· It does not affect the healing. Fistulae formation is not favoured.
· It does not interfere the heart or diaphragm movements.
· It is impermeable to biological fluids, water and blood.
· It has haemostatic effect.
· It allows the sealing of parenchyma or bronchial fistulae.
Stage of Development:
Under development/lab tested
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Spanish patent applied for but not yet granted. PCT application.

Partner sought

Type and Role of Partner Sought:
- Type of partner sought: Companies
- Specific area of activity of the partner: medical, biomedical, veterinary
- Task to be performed: Acquisition of this technology through license agreement. Technical cooperation agreements through:
· Joint development of new applications,
· Adaptation to the company´s needs,
· Technical reports and scientific assessment.
· Specific training
· Standardization services, calibration, national and international technical rules, etc.
· Staff exchange for specific periods of time (to learn specific techniques).
· Rent the internal equipment to clients that wish to continue their own tests.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06001024 Biomateriales médicos
06001017 Cirugía
02007014 Plastics, Polymers
06001013 Tecnología médica / ingeniería biomédica