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Nuevo agente desinfectante y sus mezclas contra infecciones nosocomiales

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOCZ20160920001
Publicado:
31/01/2017
Caducidad:
31/01/2018
Resumen:
Investigadores de un hospital universitario checo han sintetizado y probado una nueva sal de amonio cuaternario que se utiliza como agente desinfectante contra una amplia variedad de bacterias y hongos causantes de infecciones hospitalarias (nosocomiales). Esta sal reduce el aumento de la resistencia a preparaciones desinfectantes. La principal ventaja de estas formulaciones es la efectividad de amplio espectro contra bacterias gram negativas y positivas y patógenos (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Aspergillus niger, Bacillus subtilis) al mismo tiempo. Las formulaciones probadas no irritan la piel. El equipo de investigación, que ha solicitado la patente y modelo de utilidad, busca socios con el fin de licenciar este nuevo agente desinfectante.

Details

Tittle:
New disinfectant compound and its mixtures against nosocomial infections
Summary:
Researchers at a Czech university hospital have synthesized and tested a new quaternary ammonium salt developed as disinfectant agent, applicable against a wide variety of originators of hospital bacterial and fungal (nosocomial) infections and likewise limiting the development of resistance to disinfectant preparations. Patent application and utility model are filed. Researchers are looking for partners for licensing of new disinfectant compound.
Description:
Resistance to bacterial strains currently presents one of the most challenging problems in the field of disinfectant preparations. The problem relates not only to the resistance to antibiotics but also the general resistance to commonly used disinfectant preparations. These strains, called multi-resistant, are resistant to both families of antimicrobial agents. This trend results from long term usage of antibiotics and disinfectant preparations, especially in hospitals where the bacteria are constantly exposed to selective pressure of antibiotics and they are able to become resistant to common disinfectant preparations.
Resistance to antimicrobial compounds is either primary, expressed as absence (or non-availability) of the target structure for the disinfectant agent, or secondary, that gradually forms at an originally sensitive strain. Hospital infections are caused by a wide variety of bacteria and fungi present at hospital environment. The probability of their break out rises especially at immunodeficient patients. Quaternary ammonium compounds are widely applicable. They are used as disinfectants, surfactants, textile softeners, or antistatic agents. Benzalkonium salts (N-alkyl, N-benzyl, N,N-dimethylamine) with the alkyl chains of the length of C10-C18 are commonly used in food industry to protect the food, drugs, and other products to various microorganisms including fungi. They prolong the expiration date and increase safety. Benzalkonium salts with C12 chain are very efficient against fungi, the salts with C14 chain against gram-positive bacteria, and the salts with C16 chain against gram-negative bacteria.
The compounds comprising a heterocycle with nitrogen heteroatom present another group of compounds structurally similar to benzalkonium salts. These compounds are not so widely used comparing to benzalkonium salts. However, for example cetylpyridium is known as an efficient disinfectant and protection preparation, thus it is a part of many medical preparations. In contrast to this commonly used compound, their new compound and the disinfectant composition according to the invention are expected to have a low probability of microbial resistance development. Thus, they present a suitable alternative for complementing the choice of preparations currently used in disinfectant programmes in hospitals, food industry and the like.

The object of the invention by the Czech researchers is a new quaternary ammonium salt developed as the disinfectant agent applicable against a wide variety of originators of hospital bacterial and fungal infections and likewise limiting the development of resistance to disinfectant preparations. The disinfectant composition according to the invention showed, in the performed tests, a high disinfectant efficiency against gram-negative and gram-positive bacteria and selected pathogen fungi including highly resistant microorganisms such as Aspergillus niger or Bacillus subtillis that commonly cause hospital infections. The disinfectant efficiency of the prepared compositions according to the invention was comparable with benzyldodecyl dimethylamonium bromide which presents the main active substance in many commonly available disinfectant preparations based on quaternary ammonium salts. In terms of biological safety assessment of these mixtures, they were proved to be non-irritable to the skin (both at in vitro and in vivo conditions).

The institution is seeking partners interested in licensing agreement. The subject of the licensing will be know-how and procedures for preparation of the novel disinfectant agent against a wide variety of originators of hospital bacterial and fungal infections.
Advantages and Innovations:
The main advantage of proposed formulations lies in broad-spectrum effectiveness against gram-negative, gram-positive bacteria and selected pathogenic fungi at the same time (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Aspergillus niger, Bacillus subtilis). Formulations are comparable with benzyldodecyl dimethylamonium bromide which presents the main active substance in many commonly available disinfectant preparations based on quaternary ammonium salts. In comparison with the known commercially available disinfectant mixtures currently used, there is an important difference and advantage of a low probability of resistance to microbes, as this compound is not so far commonly used as a part of disinfectant preparations. The tested formulations do not irritate the skin (in vitro condition).
Stage of Development:
Available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Patent application was filed in the Czech Republic and utility model was filed in the Czech Republic - both in 2015

Partner sought

Type and Role of Partner Sought:
The institution is seeking a leading pharmaceutical company interested in purchasing a license based on a licensing agreement. The subject of a license is a know-how for the novel disinfectant agent against a wide variety of originators of hospital bacterial and fungal infections. The partner sought is expected to manufacture the product and bringt it to the market.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
Czech
English

Keywords

Technology Keywords:
06001001 Bioestadística, epidemiología
06002008 Microbiología
06001018 Virus, virología / antibióticos / bacteriología