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Nuevo aparato de densitometría retiniana


Oferta Tecnológica
Un equipo de investigación británico ha desarrollado un aparato de densitometría retiniana para detectar la degeneración macular asociada a la edad en fase temprana midiendo los pigmentos sensibles a la luz en la mácula después de la exposición a la luz. Las principales ventajas incluyen la capacidad de analizar la adaptación a la oscuridad en un número de longitudes de onda que pueden determinarse por el operario y la integración de los sensores, instrumentos y componentes analíticos en un solo kit. Se buscan socios con el fin de establecer acuerdos de licencia.


Novel Imaging Retinal Densitometer
UK researchers have developed a retinal densitometer to detect Age Related Macular Degeneration at the earliest stages by measuring how the light sensitive pigments in the macula regenerate after exposure to light. The main advantages over current methods are the ability to test dark adaption at a number of wavelengths that can be determined by the operator and all the necessary sensors, instrumentation and analysis components are built into a single kit. A licensing opportunity is offered.
Age Related Macular Degeneration (AMD) is a common eye condition and a leading cause of vision loss among people age 50 and older. It causes damage to the macula, a small spot near the center of the retina and the part of the eye needed for sharp, central vision, which lets us see objects that are straight ahead. AMD is the most common form of some sight loss in adults and current UK medical advice is that 'AMD has few symptoms in the early stages, so it is important to have your eyes examined regularly. If you are at risk for AMD because of age, family history, lifestyle, or some combination of these factors, you should not wait to experience changes in vision before getting checked for AMD'. Currently, only a comprehensive dilated eye exam can detect AMD. The eye exam may include any or all of the following separate tests:
· Visual acuity test.
· Dilated eye exam.
· Amsler grid.
· Fluorescein angiogram.
· Optical coherence tomography.
To replace some of and perhaps all of these tests UK researchers have developed a retinal densitometer that bleaches the subject's retina and then maps the reflectance of the macula at different wavelengths at different stages over a dark recovery period (dark adaption). The densitometer has three main parts: a control unit, a head unit and an analysis unit.
The control unit is comprised of the control module, measurement module and bleaching module. The control module is responsible for the synchronisation of the light generation and the image acquisition undertaken by the measurement module. The measurement module generates illumination of predetermined wavelengths or wavelength bands, over the range of 410-850nm (nano metres), which is used to measure the reflectance of the patient's eye. The light output at each wavelength has a predetermined bandwidth, such as a bandwidth of 10 nm at FWHM. The bleaching module has a broadband light source that may be activated for a continuous period or in pulses.
The head unit is comprised of a headrest for supporting the patient's head, optics (fibre optic cable or a liquid light guide) carrying illumination from the measurement module, an eyepiece and an imaging device. The eyepiece is used to form a magnified image of the eye such that the imaging device can record a spatial map of light reflected from the macula. The imaging device may be a charge-coupled device (CCD) or a CMOS image censor.
The analysis unit holds the graphical user interface that allows the operator to perform such tasks as select the modes of operation and the wavelengths over which the eye's reflectivity will be tested.
Advantages and Innovations:
The main innovation is that the densitometer is a single kit comprising an illumination unit, an imaging device and a control unit as described above.
With advantages over current methodoligies:
Early-stage diagnosis of age-related macular degeneration with one test kit.
Switching between sources, while recording a series of images, allows measurement of changes in reflectance as a function of time and wavelength across the retina. This allows the device to map the change in optical density of the visual pigments over time.
The retinal densitometer has the ability to test dark adaption at a number of wavelengths that can be determined by the operator
Stage of Development:
Available for demonstration
Patents granted
CommeR Statunts Regarding IPR Status:
UK patents granted

Partner sought

Type and Role of Partner Sought:
The ideal partner would be a medical or optical equipment manufacturer with access to medical markets.
The role would be to develop into a production and marketable model and bring to market under licence.


Type and Size of Client:
R&D Institution
Already Engaged in Trans-National Cooperation:
Languages Spoken:


Technology Keywords:
06001005 Diagnósticos, diagnosis
06001013 Tecnología médica / ingeniería biomédica