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Nuevo biomarcador de citrulina para medir la actividad de óxido nítrico sintasa (NOS)

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOTR20150731004
Publicado:
08/02/2016
Caducidad:
08/02/2017
Resumen:
Un equipo de investigación de una universidad turca que trabaja en métodos de medición para medicina ha desarrollado un nuevo método de medición de la actividad de óxido nítrico sintasa en tejidos, importante en el campo de investigación y desarrollo de medicamentos y de utilidad para centros de investigación y compañías farmacéuticas. El nuevo biosensor se emplea para desarrollar medicamentos que aumenten la enzima óxido nítrico sintasa (eNOS) o reduzcan el óxido nítrico sintasa inducible (iNOS). Se trata de un método económico, seguro, fácil de usar y sensible. La universidad busca socios para cooperar en la investigación y continuar con el desarrollo del método.

Details

Tittle:
A novel citrulline biomarker to measure NOS (nitric oxide synthases) activity
Summary:
A Turkish research group at a university has been working on medical measurement methods. This group has developed a new measurement method for NOS activity from tissue, which is important for drug development research and useful for pharmaceutical companies and research centers. The university is looking for research cooperation partners for further development of the method.
Description:
A Turkish university has developed a novel citrulline biosensor which can measure NOS (nitric oxide synthases) activity in the presence of NOS substrate and cofactors has been developed. The advantage of the new method is cheap, safe, easily operated and also sensitive. The developed new biosensor can be used in development of drugs to increase eNOS or decrease iNOS. It can also be used as biomarker where NOS activity decreased (e.g., diabetes, atherosclerosis, erectile
dysfunction, chronic kidney and heart failure). Another advantage of the developed biosensor is having no need for extra modifications for working. In addition, the developed biosensor could be used for measuring L-citrulline levels in pathological conditions involving a marker to detect severe renal impairment and function of small bowel in several
pathologies as well as alzheimer disease and rheumatoid arthritis.

The university is interested in further development of the method thus is seeking for partners for research cooperation.
Advantages and Innovations:
-NO (nitric oxide) can be measured by griess assay, which is based on nitrite and nitrate measurement colorimetrically or by biosensor directly. However, measuring NO does not mean measuring NO production since it can measure available NO and does not reflect NOS (nitric oxide synthases) activity.
Beside in griess assay protein nitrosylation and some foods containing nitrogenous compounds could contribute to higher measurement of NO amount.
-NOS activity can be only measured by a radioactive assay which is not user-and environmentally friendly.
Stage of Development:
Prototype available for demonstration
IPs:
Patent(s) applied for but not yet granted
CommeR Statunts Regarding IPR Status:
Patent appliacation is made for Turkey.

Partner sought

Type and Role of Partner Sought:
Partners interested with research cooperation for development of the method are sought. Experience in related area will be evaluated.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
Si
Languages Spoken:
English

Keywords

Technology Keywords:
09001009 Tecnología de sensores relacionada con la realización de medidas