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Nuevo biovidrio para injertos e implantes óseos

Resumen

Tipo:
Oferta Tecnológica
Referencia:
TOES20160801002
Publicado:
21/09/2016
Caducidad:
21/09/2017
Resumen:
Una universidad andaluza, en colaboración con dos centros de investigación españoles, ofrece injertos e implantes médicos hechos con nitri-biovidrios para usos médicos en regeneración ósea e ingeniería de tejidos. Los nitri-biovidrios pueden emplearse como andamios temporales en implantes óseos o cirugía reconstructiva. Los experimentos in vitro han demostrado que las células óseas cultivadas con estos biovidrios tienen un crecimiento y diferenciación mejorados. La universidad busca socios industriales interesados en establecer acuerdos de cooperación técnica y licencia.


Details

Tittle:
Novel bio glass material for bone implants and grafts.
Summary:
An Andalusian University, with the collaboration of two research centers of Spain, offers medical grafts and implants made with a novelty Nitri-bioglasses for medical uses in bone regeneration and tissue engineering, able to be used as temporal scaffolds in bone implants or reconstructive surgery. The University is looking for industrial partners interested in technical cooperation and license agreements.
Description:
Bioactive glass is one of the most promising materials as a bone substitute and temporary scaffolds for tissue engineering. Compared to ceramic materials which are made with calcium phosphates, the bio glasses can be also enriched with ions that enhance osteopathy induction and therefore the growth of bone cells.
An Andalusian University and two Research Centers of Spain have obtained a highly porous bio glass. On its surface nitride groups have been added, in order to improve the cell regeneration. By its quickly biodegradation, highly bio activity and better adaptation to bone cells, represents an enhancing material compared with non nitrored materials. In vitro experiments have shown that bone cells cultivated with these bio glasses have an improved growth and differentiation.
The scientific team that has developed this technology has extensive experience in Regenerative Medicine of skeleton tissues. It is composed for researchers specialized on: new ceramic materials and glasses studies with high experience on skeletal regeneration in animal models and its therapeutic osteogenesis, searching for its applications within the area of Regenerative Medicine of skeleton tissue.

The University is looking for industrial partners interested in further development under the technical cooperation agreement and those interested in in-licensing of this innovative bio glass for several implants.
Advantages and Innovations:
There are three essential elements in the case of implants: mechanical consistence, biodegradation and osteo inductive capacity. The implant has to dissolve and help the bone regeneration at the same time that maintains its mechanical consistency. Reducing the biodegradation rate improves the dissolution of the material and bone´s growth. In this sense, the obtained bioglass is mechanically stable with a quicker biodegradation ratio.
But the most innovative aspect it´s on the chemical surfaces of the material where - NH and -NH2 groups have been added.
These chemical radicals, which are essential components of proteins and peptides, create an improved biological medium which enhances the cell´s growth. From a practical point of view, this supposes an improved and faster cellular regeneration, because cells attach to bioglass, grow and differentiate better.
At the end, it enhances the adhesion and growth of new cells.
Stage of Development:
Available for demonstration
IPs:
Patent(s) applied for but not yet granted

Partner sought

Type and Role of Partner Sought:
Type of partner: Biomedical Engineering companies interested in new biomaterials for tissue engineering.

Field of activity: These bioglasses could be used cranial and maxillofacial surgery, for the treatment of pathologies such as the osteonecrosis of the jaw, which has a low success rate. Also, in reconstructive surgery of congenital malformations in children, as in children metal stents cannot be used and the current bones substitutes are not efficient.

Task to be performed: The scientific team is searching now companies interested in continuing the research in order to develop and commercialize this material.

Client

Type and Size of Client:
University
Already Engaged in Trans-National Cooperation:
No
Languages Spoken:
English
Spanish

Keywords

Technology Keywords:
06001 Medicina, salud humana